The use of phase inversion temperature (PIT) microemulsion technology to enhance oil utilisation during Streptomyces rimosus fed-batch fermentations to produce oxytetracycline

摘要

The use of a rapeseed oil emulsion feed,produced by a phase inversion temperature (PIT) process,produced more biomass,gave a 3-fold increase in oil utilisation and a higher oxytetracycline titre but a higher residual oil concentration when compared to a conventional fed-batch Streptomyces rimosus process fed with crude rapeseed oil.Importantly,microbial utilisation of the surfactant was confirmed for the first time.