長鎖ノンコーディングRNAのためのバイオインフォマティクス

摘要

Recent advances in high throughput sequencing technologies unveiled that large number of long non-coding RNAs (IncRNAs) are transcribed from human genome, Currently, these emerging transcripts are needed to be functionally classified and annotated. Here we review several bioinformatic approaches for analyzing the important characteristics of the IncRNAs toward discovering their functions: 1)tissue specificities of IncRNA expressions, 2) two types of macromolecular interactions (RNA-RNA and RNA-protein interactions), 3) secondary structures of IncRNAs.