Restriction of dietary protein and long-term outcomes in patients with CKD.

摘要

The posttrial analysis by Dr Menon and colleagues concluded that assignment of a very low-protein diet (VLPD) increases the risk of death in patients with chronic kidney disease.However, a satisfying biological or scientific hypothesis for the relation between time-limited exposure to a VLPD and long-term outcomes is not provided. In addition, the long period without dietary treatment (dilution effect) and the many confounders (lack of information for transplantation, starting dialysis criteria, dialysis type, vascular access, and so on) preclude a conclusive judgment about the safety of a VLPD