Light Chain Deposition Disease After Renal Transplantation

摘要

Light chain deposition disease (LCDD) is char-f acterized by the deposition of k or A iraniu-noglobulin light chains in many organs, including the kidney. The disease frequently is associated with multiple myeloma or other Iym-phoplasmacytic proliferative disorders, although a significant number of patients with LCDD show no evidence of bone marrow abnormalities. LCDD frequently has been reported to recur after renal transplantation, inevitably followed by graft failure. Multiple myeloma also has been considered a major cause of light chain deposition in renal allografts and to show a high rate of recurrence.