Correlation between soluble interleukin-2 receptor levels and modified Rodnan total skin thickness scores in a patient with generalized morphea: A case report

摘要

Generalized morphea is a rare condition in which idi-opathic sclerosis of the skin occurs in a widespread manner. It usually starts on the trunk and is not associated with systemic disturbances.1 Interleukin-2 receptor (ILr2R) is a membranous glycoprotein that forms the high-affinity IL-2 receptor. The soluble form (sII^2R) is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.2 Here, we describe in detail a correlation between soluble IL-2R levels and modified Rod-nan total skin thickness scores (mRTSS) in a patient with generalized morphea treated with topical corticosteroids.A 79-year-old Japanese woman was referred to our department for diagnosis of sclerotic skin with erythema on the chest, abdomen, waist, and right lower leg (Fig. la). The sclerotic skin of the abdomen had a 5-month history and the symptoms gradually spread to the chest, waist, and right lower leg. She had no medical history of note. Her younger sister had died due to collagen disease, but the patient did not know the accurate diagnosis.