Dolutegravir monotherapy in SIV-infected macaques leads - despite the emergence of resistance mutations - to sustained antiviral and clinical benefits

Van Rompay Koen K. A.; Lifson Jeffrey; Keele Brandon; Houssanah Said; Watanabe Jennifer; Chertova Elena; Sowder Raymond; Balzarini Jan; Wainberg Mark A.

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Dolutegravir monotherapy in SIV-infected macaques leads - despite the emergence of resistance mutations - to sustained antiviral and clinical benefits

机译：在SIV感染的Macaques的DoluteGravir单一疗法 - 尽管存在抗性突变 - 持续抗病毒和临床效益

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来源
《Journal of medical primatology》 |2017年第4期|共2页
作者
Van Rompay Koen K. A.; Lifson Jeffrey; Keele Brandon; Houssanah Said; Watanabe Jennifer; Chertova Elena; Sowder Raymond; Balzarini Jan; Wainberg Mark A.;
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Univ Calif Davis Davis CA 95616 USA;

Frederick Natl Lab Frederick MD USA;

Frederick Natl Lab Frederick MD USA;

McGill Univ AIDS Ctr Lady Davis Inst Med Res Montreal PQ Canada;

Univ Calif Davis Davis CA 95616 USA;

Frederick Natl Lab Frederick MD USA;

Frederick Natl Lab Frederick MD USA;

Katholieke Univ Leuven Rega Inst Med Res Leuven Belgium;

McGill Univ AIDS Ctr Lady Davis Inst Med Res Montreal PQ Canada;

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正文语种 eng
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1. Dolutegravir monotherapy in SIV-infected macaques leads - despite the emergence of resistance mutations - to sustained antiviral and clinical benefits [J] . Van Rompay Koen K. A., Lifson Jeffrey, Keele Brandon, Journal of medical primatology . 2017,第4期

机译：在SIV感染的Macaques的DoluteGravir单一疗法 - 尽管存在抗性突变 - 持续抗病毒和临床效益
2. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection [J] . Koen KA Van Rompay, Jeffrey A Johnson, Emily J Blackwood, Retrovirology . 2007,第S1期

机译：在长期RT-SHIV感染恒河猴中长期替诺福韦单药治疗期间，逆转录酶中具有K70E和K65R突变的病毒突变体的顺序出现和临床意义
3. Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir [J] . Jomy M George, Safia S Kuriakose, Nicola Dee, Open Forum Infectious Diseases . 2018,第10期

机译：在两名对Dolutegravir有基线部分敏感性的有治疗经验的个体中，随着T97A突变的出现，对Dolutegravir的高水平耐药性的快速发展
4. Dynamic Process Management towards Sustained Compliance and Benefit in Clinical Research [C] . Rita Hattemer-Apostel, Martin Simon International conference of the System Dynamics Society . 2003

机译：动态过程管理，确保临床研究的持续合规性和效益
5. The role of sustained antibody-dependent cell-mediated cytotoxicity (ADCC) in SIV-infected macaques in the delayed progression to AIDS. [D] . Banks, Nia Danielle. 2003

机译：在SIV感染的猕猴中，持续的抗体依赖性细胞介导的细胞毒性（ADCC）在延缓向AIDS进程中的作用。
6. Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes [O] . Koen K. A. Van Rompay, Said Hassounah, Brandon F. Keele, 2019

机译：猿猴免疫缺陷病毒感染猕猴的Dolutegravir单一疗法选择了具有可变病毒学结果的几种耐药突变型
7. Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes [O] . Koen K. A. Van Rompay, Said Hassounah, Brandon F. Keele, 2019

机译：Simian免疫缺陷病毒感染的猕猴的Dolutegravir单一疗法选择了几种抗性病毒学结果的抗性突变模式

Dolutegravir monotherapy in SIV-infected macaques leads - despite the emergence of resistance mutations - to sustained antiviral and clinical benefits

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