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Molecular suitability of the chacma baboon in human‐targeted Von Willebrand factor directed studies

机译：Chacma Bakoon在人靶向von Willebrand系数研究的分子适用性

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Abstract <section numbered="no" xml:id="jmp12407-sec-0001"> <title type="main">Background > Von Willebrand factor ( <fc>VWF</fc> ) has a central role in primary haemostasis and is a popular pharmaceutical target in the prevention and treatment of disorders such as acute coronary syndrome and thrombotic thrombocytopenic purpura. We have evaluated numerous possible treatments targeting <fc>VWF</fc> in the chacma baboon. Unfortunately, no data exist regarding the molecular similarity of the chacma baboon and human <fc>VWF</fc> protein, resulting in limited translatability of results. </section> <section numbered="no" xml:id="jmp12407-sec-0002"> <title type="main">Methods > Sanger sequencing was performed of the functionally vital <fc>VWF</fc> exon 28. The sequences were then compared to the human reference sequence. </section> <section numbered="no" xml:id="jmp12407-sec-0003"> <title type="main">Results > The baboon and human <fc>VWF</fc> amino acid sequences were 99.1% similar, with only 4 radical amino acid changes found. No radical amino acid changes were found within the functionally vital areas of the amino acid sequence. </section> <section numbered="no" xml:id="jmp12407-sec-0004"> <title type="main">Conclusion > The chacma baboon <fc>VWF</fc> is similar enough to the human to produce reliable and translatable pre‐clinical results with human‐targeted anti‐ <fc>VWF</fc> agents. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“JMP12407-ABS-AB-ABS-0001”XML：LANG =“en”> <标题类型=“main”>抽象</ title> <secueeded =“no”xml：id = “JMP12407-SEC-0001”> <标题类型=“main”>背景</ title> > von Willebrand因子（<FC> VWF </ FC>）在初级呼吸症中具有核心作用，是一个受欢迎的药物目标在预防和治疗症症等急性冠状动脉综合征和血栓形成血小板减少紫癜等疾病。我们评估了靶向CHACMA狒狒中的靶向<FC> VWF </ FC>的许多可能的治疗方法。遗憾的是，没有关于CHACMA狒狒和人类<Fc> VWF </ Fc>蛋白的分子相似性的数据，从而导致结果的可相位性有限。 </ p> </段> <部分编号=“否”XML：ID =“JMP12407-SEC-0002”> <标题类型=“main”>方法</ title> > Sanger测序在功能上执行重要的 <fc> vwf </ i>外显子28.然后将序列与人参考序列进行比较。 </ p> </ section> <secto numbyed =“no”xml：id =“jmp12407-sec-0003”> <标题类型=“main”>结果</ title> >狒狒和human <fc> VWF </ FC>氨基酸序列相似99.1％，发现仅发现4种自由基氨基酸变化。在氨基酸序列的功能性重要区域内没有发现氨基酸变化。 </ p> </ section> <部分编号=“否”XML：ID =“JMP12407-SEC-0004”> <标题类型=“main”>结论</ title> > CHACMA BUBOON <FC> VWF与人类相似，可以通过人靶向抗-CC> VWF </ Fc>试剂产生可靠和可翻译的预临床结果。 </ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2019年第3期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Janse van Rensburg Walter J.&option=202" target="_blank" rel="nofollow">Janse van Rensburg Walter J.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Human Molecular Biology UnitSchool of Biomedical SciencesBloemfontein South Africa;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=exon 28&option=203" rel="nofollow">exon 28;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=molecular characterisation&option=203" rel="nofollow">molecular characterisation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sanger sequencing&option=203" rel="nofollow">Sanger sequencing;</a> </p> <div class="translation"> 机译：外显子28;分子表征;Sanger测序; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993011.html">Molecular suitability of the chacma baboon in human‐targeted Von Willebrand factor directed studies</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Janse van Rensburg Walter J.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Janse van Rensburg Walter J. </a> <a href="/journal-foreign-36449/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of medical primatology .</a> <span>2019</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Chacma Bakoon在人靶向von Willebrand系数研究的分子适用性</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024919960.html">Unraveling the Influence of Common von Willebrand factor variants on von Willebrand Disease Phenotype: An Exploratory Study on the Molecular and Clinical Profile of von Willebrand Disease in Spain Cohort</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <a href="/journal-foreign-31484/" target="_blank" rel="nofollow" class="tuijian_authcolor">Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis .</a> <span>2020</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：解开常见的von Willebrand因子变种对冯维尔布朗疾病表型的影响：西班牙群岛冯维尔布朗疾病分子与临床剖面的探索性研究</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704015696234.html">Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD): a rebuttal.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Favaloro EJ&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Favaloro EJ </a> <a href="/journal-foreign-36185/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of thrombosis and haemostasis: JTH .</a> <span>2008</span><span>,第11期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：欧洲研究中对von Willebrand病患者进行的详细von Willebrand因子多聚体分析，诊断和治疗1型von Willebrand病（MCMDM-1VWD）的分子和临床标记：驳斥。</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-192654_thesis/020512999195.html">Surface Dependent Expression of Platelet GPIb Binding Domain Within Human von Willebrand Factor Studied by Atomic Force Microscopy</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Inkyung Kang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Inkyung Kang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Madhusudan Raghavachari&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Madhusudan Raghavachari,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roger E. 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tuijian_authcolor"> . 王琪</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120101390040.html">一种miR-21-5p靶向Smad7调控猪卵巢颗粒细胞的分子机制研究方法及其应用</a> <b>[P]</b> . <span> 中国专利： CN110511903A </span> <span> . 2019-11-29</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120111664302.html">一种靶向沉默STAT3对人脑胶质瘤U251细胞缺氧诱导影响的研究方法及其应用</a> <b>[P]</b> . <span> 中国专利： CN111607616A </span> <span> . 2020-09-01</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130467317115.html">MOLECULAR CLONING OF cDNA FOR HUMAN FACTOR VIIIR (VON WILLEBRAND FACTOR).</a> <b>[P]</b> . <span> 外国专利：  EP0222003A4 </span> <span> . 1989-03-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类因子VIIIR（VON WILLEBRAND因子）cDNA的分子克隆。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130470028687.html">MOLECULAR CLONING OF cDNA FOR HUMAN FACTOR VIIIR (VON WILLEBRAND FACTOR)</a> <b>[P]</b> . <span> 外国专利：  EP0222003A1 </span> <span> . 1987-05-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类因子VIIIR（VON WILLEBRAND因子）cDNA的分子克隆 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130470136938.html">MOLECULAR CLONING OF cDNA FOR HUMAN FACTOR VIIIR (VON WILLEBRAND FACTOR).</a> <b>[P]</b> . <span> 外国专利：  ES8800353A1 </span> <span> . 1987-11-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类因子VIIIR（VON WILLEBRAND因子）cDNA的分子克隆。 </span> </p> </li> </ul> </div> </div> </div> <div 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