Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

摘要

Omentin is predominantly secreted by the stromal vascular fraction of visceral adipose tissue.1 Currently available studies controversially discuss whether omentin exerts a protective or detrimental role in type 2 diabetes (T2D) and cardiovascular diseases (CVD).Cross‐sectional studies found decreased circulating levels of omentin in obese compared with lean individuals and lower omentin levels in patients with T2D compared with glucose tolerant people.2, 3 In a cross‐sectional analysis of the Cooperative Health Research in the Region of Augsburg (KORA) F4 study, we observed that omentin did not differ between individuals ranging from normal glucose tolerance to T2D.4 However, higher circulating omentin was inversely associated with multiple risk factors for T2D and CVD.2-5 These findings were supported by in vitro studies showing that omentin increased Akt phosphorylation and insulin‐stimulated glucose uptake in human adipocytes.1