Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebocontrolled, double-blind, parallel-group study

Frandsen Christian S.; Dejgaard ThomasF.; Andersen Henrik U.; Holst Jens J.; Hartmann Bolette; Thorsteinsson Birger; Madsbad Sten

首页> 外文期刊>Diabetes, obesity & metabolism >Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebocontrolled, double-blind, parallel-group study

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Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebocontrolled, double-blind, parallel-group study

机译：Liraglutide作为1型糖尿病患者的胰岛素治疗的辅助，不会干扰低血糖期间的血糖恢复或胃排空率：随机，不安放的，双盲，并行组研究

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Aim: Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is a potential treatment as adjunct to insulin in type 1 diabetes (T1D). However, GLP-1RAs inhibit glucagon secretion and delay the gastric emptying (GE) rate and may impair recovery from hypoglycaemia. We evaluated the effect of the GLP-1RA liraglutide on counterregulatory responses and GE rate during hypoglycaemia in persons with T1D.

机译：目的：胰高血糖素类肽-1受体激动剂（GLP-1RA）治疗是一种潜在的治疗，如1型糖尿病（T1D）的胰岛素辅助。然而，GLP-1RAS抑制胰高血糖素分泌并延迟胃排空（GE）率，可能损害低血糖血症。我们评估了GLP-1RA Liraglutide对T1D的人群的低血糖期间对反应性反应和GE率的影响。

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来源
《Diabetes, obesity & metabolism》 |2017年第6期|共10页
作者
Frandsen Christian S.; Dejgaard ThomasF.; Andersen Henrik U.; Holst Jens J.; Hartmann Bolette; Thorsteinsson Birger; Madsbad Sten;
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作者单位

Univ Copenhagen Hvidovre Hosp Dept Endocrinol Hvidovre Denmark;

Univ Copenhagen Hvidovre Hosp Dept Endocrinol Hvidovre Denmark;

Steno Diabet Ctr Gentofte Denmark;

Univ Copenhagen Dept Biomed Sci Copenhagen Denmark;

Univ Copenhagen Dept Biomed Sci Copenhagen Denmark;

Univ Copenhagen Dept Cardiol Nephrol &

Endocrinol Nordsjaellands Hosp Hillerod Hillerod Denmark;

Univ Copenhagen Hvidovre Hosp Dept Endocrinol Hvidovre Denmark;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
gastric emptying; GLP-1 analogue; glucagon; hypoglycaemia; liraglutide; randomized trial; type 1 diabetes;

机译：胃排空;GLP-1类似物;胰高血糖素;低血糖;Liraglutide;随机试验;1型糖尿病;

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1. Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebocontrolled, double-blind, parallel-group study [J] . Frandsen Christian S., Dejgaard ThomasF., Andersen Henrik U., Diabetes, obesity & metabolism . 2017,第6期

机译：Liraglutide作为1型糖尿病患者的胰岛素治疗的辅助，不会干扰低血糖期间的血糖恢复或胃排空率：随机，不安放的，双盲，并行组研究
2. Design and methods of a randomised double-blind trial of adding liraglutide to control HbA1c in patients with type 2 diabetes with impaired glycaemic control treated with multiple daily insulin injections (MDI-Liraglutide trial) [J] . Lind Marcus, Hirsch Irl B., Tuomilehto Jaakko, Primary care diabetes . 2015,第1期

机译：在每天两次胰岛素注射治疗的血糖控制受损的2型糖尿病患者中，加入利拉鲁肽控制HbA1c的随机双盲试验的设计和方法（MDI-利拉鲁肽试验）
3. Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal-bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN? Basal-Bolus Type 1): 2-year results of a randomized clinical trial [J] . BodeB.W., BuseJ.B., FisherM., Diabetic medicine: A journal of the British Diabetic Association . 2013,第11期

机译：在1型糖尿病（BEGIN？Basal-Bolus 1型）中，就餐时服用门冬胰岛素的基础大剂量治疗，胰岛素degludec可以比甘精胰岛素改善夜间血糖低的血糖控制风险：一项为期2年的随机临床试验结果
4. Nonlinear Insulin to Carbohydrate Rule for Treatment of Type 1 Diabetes [C] . Graham C. Goodwin, Diego S. Carrasco, Adrian M. Medioli, IFAC Conference on Modelling, Identification and Control of Nonlinear Systems . 2016

机译：非线性胰岛素到碳水化合物规则治疗1型糖尿病
5. Feasibility Study of a Randomized Controlled Trial Protocol to Examine the Effectiveness of Auriculotherapy (AT) in Improving Sleep Condition and Glycaemic Control in Clients with Type 2 Diabetes. [D] . Kwan, Yee Mei. 2013

机译：一项随机对照试验方案的可行性研究，以检查耳穴疗法（AT）改善2型糖尿病患者睡眠状况和血糖控制的有效性。
6. Short Report: Treatment Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal–bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN® Basal–Bolus Type 1): 2-year results of a randomized clinical trial [O] . B W Bode, J B Buse, M Fisher, -1

机译：简短报告：在1型糖尿病（BEGIN®Basal-Bolus 1型）中就餐时服用门冬胰岛素的基础-大剂量治疗胰岛素地格曲德改善血糖控制的夜间低血糖风险低于甘精胰岛素其2年随机临床试验结果
7. Insulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal–bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN ® Basal–Bolus Type 1): 2‐year results of a randomized clinical trial [O] . B. W. Bode, J. B. Buse, M. Fisher, 2013

机译：胰岛素Degludec在基底胰岛素Aspart在1型糖尿病（Begin®Basal-Zolus 1）中的胰岛素胰岛素中，胰岛素Degludec提高了夜间低血糖症的风险低于胰岛素胰岛素的血糖控制：2年的随机临床试验结果

Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebocontrolled, double-blind, parallel-group study

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