Impact of vascular calcification on QT interval and QT dispersion in CKD and dialysis patients

摘要

Dear Editor,We read with great interest the paper by Claes et al. [1]. Of 193 patients referred for renal transplantation, the authors observed a prolonged QT interval in 26% and an independent and direct association between corrected QT duration and extent of aortic calcifications (p = 0.0004) independent of age, gender, cardiovascular history, electrolytes and parameters of mineral metabolism. They concluded that a prolonged QT interval is prevalent in patients with chronic kidney disease (CKD) stage 5D. Claes et al. [1] affirm that 'to the best of our knowledge, only one study so far has reported on the association between QT duration and arterial calcification in renal patients'. Di Iorio et al. [2] found an association between QT dispersion (QT-d), but not QT-c interval duration and arterial calcifications. However, the study included patients at different stages of CKD and was hampered by the small sample size.