Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh Naomi; Zhang Han; Hyland Paula L.; Yang Qi; Mocci Evelina; Zhang Mingfeng; Childs Erica J.; Collins Irene; Wang Zhaoming; Arslan Alan A.; Beane-Freeman Laura; Bracci Paige M.; Canzian Federico; Duell Eric J.; Gallinger Steven; Giles Graham G.; Goodman Gary E.; Goodman Phyllis J.; Kooperberg Charles; LeMarchand Loic; Neale Rachel E.; Olson Sara H.; Scelo Ghislaine; Shu Xiao O.; Van den Eeden Stephen K.; Visvanathan Kala; White Emily; Zheng Wei; Albanes Demetrius; Andreotti Gabriella; Babic Ana; Bamlet William R.; Berndt Sonja I.; Borgida Ayelet; Boutron-Ruault Marie-Christine; Brais Lauren; Brennan Paul; Bueno-de-Mesquita Bas; Buring Julie; Chaffee Kari G.; Chanock Stephen; Cleary Sean; Cotterchio Michelle; Foretova Lenka; Fuchs Charles; Gaziano J. Michael M.; Giovannucci Edward; Goggins Michael; Hackert Thilo; Haiman Christopher; Hartge Patricia; Hasan Manal; Helzlsouer Kathy J.; Herman Joseph; Holcatova Ivana; Holly Elizabeth A.; Hoover Robert; Hung Rayjean J.; Janout Vladimir; Klein Eric A.; Kurtz Robert C.; Laheru Daniel; Lee I-Min; Lu Lingeng; Malats Nuria; Mannisto Satu; Milne Roger L.; Oberg Ann L.; Orlow Irene; Patel Alpa V.; Peters Ulrike; Porta Miquel; Real Francisco X.; Rothman Nathaniel; Sesso Howard D.; Severi Gianluca; Silverman Debra; Strobel Oliver; Sund Malin; Thornquist Mark D.; Tobias Geoffrey S.; Wactawski-Wende Jean; Wareham Nick; Weiderpass Elisabete; Wentzensen Nicolas; Wheeler William; Yu Herbert; Zeleniuch-Jacquotte Anne; Kraft Peter; Li Donghui; Jacobs Eric J.; Petersen Gloria M.; Wolpin Brian M.; Risch Harvey A.; Amundadottir Laufey T.; Yu Kai; Klein Alison P.; Stolzenberg-Solomon Rachael Z.

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Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

机译：易毒性途径/基因集分析基因组关联数据识别胰腺癌的关联

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Background Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

机译：背景技术基因组 - 宽协会研究（GWAS）鉴定各单核苷酸多态性（SNP）与癌症风险的关联，但通常只解释继承变异性的一小部分。遗传变异的途径分析是识别易感基因网络的强大工具。

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来源
《Journal of the National Cancer Institute》 |2019年第6期|共11页
作者
Walsh Naomi; Zhang Han; Hyland Paula L.; Yang Qi; Mocci Evelina; Zhang Mingfeng; Childs Erica J.; Collins Irene; Wang Zhaoming; Arslan Alan A.; Beane-Freeman Laura; Bracci Paige M.; Canzian Federico; Duell Eric J.; Gallinger Steven; Giles Graham G.; Goodman Gary E.; Goodman Phyllis J.; Kooperberg Charles; LeMarchand Loic; Neale Rachel E.; Olson Sara H.; Scelo Ghislaine; Shu Xiao O.; Van den Eeden Stephen K.; Visvanathan Kala; White Emily; Zheng Wei; Albanes Demetrius; Andreotti Gabriella; Babic Ana; Bamlet William R.; Berndt Sonja I.; Borgida Ayelet; Boutron-Ruault Marie-Christine; Brais Lauren; Brennan Paul; Bueno-de-Mesquita Bas; Buring Julie; Chaffee Kari G.; Chanock Stephen; Cleary Sean; Cotterchio Michelle; Foretova Lenka; Fuchs Charles; Gaziano J. Michael M.; Giovannucci Edward; Goggins Michael; Hackert Thilo; Haiman Christopher; Hartge Patricia; Hasan Manal; Helzlsouer Kathy J.; Herman Joseph; Holcatova Ivana; Holly Elizabeth A.; Hoover Robert; Hung Rayjean J.; Janout Vladimir; Klein Eric A.; Kurtz Robert C.; Laheru Daniel; Lee I-Min; Lu Lingeng; Malats Nuria; Mannisto Satu; Milne Roger L.; Oberg Ann L.; Orlow Irene; Patel Alpa V.; Peters Ulrike; Porta Miquel; Real Francisco X.; Rothman Nathaniel; Sesso Howard D.; Severi Gianluca; Silverman Debra; Strobel Oliver; Sund Malin; Thornquist Mark D.; Tobias Geoffrey S.; Wactawski-Wende Jean; Wareham Nick; Weiderpass Elisabete; Wentzensen Nicolas; Wheeler William; Yu Herbert; Zeleniuch-Jacquotte Anne; Kraft Peter; Li Donghui; Jacobs Eric J.; Petersen Gloria M.; Wolpin Brian M.; Risch Harvey A.; Amundadottir Laufey T.; Yu Kai; Klein Alison P.; Stolzenberg-Solomon Rachael Z.;
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Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Johns Hopkins Sch Med Dept Oncol Sidney Kimmel Comprehens Canc Ctr Baltimore MD USA;

NCI Lab Translat Genom Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Lab Translat Genom Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Lab Translat Genom Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NYU Sch Med Dept Obstet &

Gynecol New York NY USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Univ Calif San Francisco Dept Epidemiol &

Biostat San Francisco CA 94143 USA;

German Canc Res Ctr Genom Epidemiol Grp Heidelberg Germany;

Catalan Inst Oncol ICO Bellvitge Biomed Res Inst IDIBELL Unit Nutr &

Canc Canc Epidemiol Res;

Sinai Hlth Syst Prosserman Ctr Populat Hlth Res Lunenfeld Tanenbaum Res Inst Toronto ON Canada;

Canc Council Victoria Canc Epidemiol &

Intelligence Div Melbourne Vic Australia;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

Fred Hutchinson Canc Res Ctr SWOG Stat Ctr 1124 Columbia St Seattle WA 98104 USA;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

QIMR Berghofer Med Res Inst Populat Hlth Dept Brisbane Qld Australia;

Mem Sloan Kettering Canc Ctr Dept Epidemiol &

Biostat New York NY 10021 USA;

Vanderbilt Univ Sch Med Vanderbilt Epidemiol Ctr Div Epidemiol Dept Med Vanderbilt Ingram Canc;

Johns Hopkins Bloomberg Sch Publ Hlth Dept Epidemiol Baltimore MD USA;

Vanderbilt Univ Sch Med Vanderbilt Epidemiol Ctr Div Epidemiol Dept Med Vanderbilt Ingram Canc;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Mayo Clin Coll Med Dept Hlth Sci Res Rochester MN USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Univ Paris Saclay Ctr Rech Epidemiol &

Sante Populat Fac Med INSERM U1018 UPS UVSQ Gustave;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Natl Inst Publ Hlth &

Environm RIVM Dept Determinants Chron Dis Bilthoven Netherlands;

Brigham &

Womens Hosp Div Prevent Med 75 Francis St Boston MA 02115 USA;

Mayo Clin Coll Med Dept Hlth Sci Res Rochester MN USA;

Univ Toronto Canc Care Ontario Toronto ON Canada;

Masaryk Mem Canc Inst Dept Canc Epidemiol &

Genet Brno Czech Republic;

Yale Canc Ctr New Haven CT USA;

Brigham &

Womens Hosp Div Aging 75 Francis St Boston MA 02115 USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Univ Hosp Heidelberg Dept Gen Surg Heidelberg Germany;

Univ Southern Calif Keck Sch Med Dept Prevent Med Los Angeles CA USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Univ Texas MD Anderson Canc Ctr Dept Epidemiol Houston TX 77030 USA;

NCI Div Canc Control &

Populat Sci NIH Bethesda MD 20892 USA;

Johns Hopkins Sch Med Dept Radiat Oncol Sidney Kimmel Comprehens Canc Ctr Baltimore MD USA;

Charles Univ Prague Fac Med 2 Inst Publ Hlth &

Prevent Med Prague Czech Republic;

Univ Calif San Francisco Dept Epidemiol &

Biostat San Francisco CA 94143 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Univ Ostrava Fac Med Dept Epidemiol &

Publ Hlth Ostrava Czech Republic;

Cleveland Clin Glickman Urol &

Kidney Inst Cleveland OH 44106 USA;

Brigham &

Womens Hosp Div Prevent Med 75 Francis St Boston MA 02115 USA;

Natl Inst Hlth &

Welf Dept Publ Hlth Solut Helsinki Finland;

Canc Council Victoria Canc Epidemiol &

Intelligence Div Melbourne Vic Australia;

Mayo Clin Coll Med Dept Hlth Sci Res Rochester MN USA;

Mem Sloan Kettering Canc Ctr Dept Epidemiol &

Biostat New York NY 10021 USA;

Amer Canc Soc Epidemiol Res Program Atlanta GA 30329 USA;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

CIBERESP Barcelona Spain;

CIBERONC Madrid Spain;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Brigham &

Womens Hosp Div Prevent Med 75 Francis St Boston MA 02115 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Univ Hosp Heidelberg Dept Gen Surg Heidelberg Germany;

Umea Univ Dept Surg &

Perioperat Sci Umea Sweden;

Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

SUNY Buffalo Dept Epidemiol &

Environm Hlth Buffalo NY USA;

Informat Management Syst Silver Spring MD USA;

Univ Hawaii Canc Epidemiol Program Ctr Canc Honolulu HI 96822 USA;

NYU Sch Med Dept Populat Hlth New York NY USA;

Harvard TH Chan Sch Publ Hlth Dept Epidemiol Boston MA USA;

Amer Canc Soc Epidemiol Res Program Atlanta GA 30329 USA;

Mayo Clin Coll Med Dept Hlth Sci Res Rochester MN USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Yale Sch Publ Hlth Dept Chron Dis Epidemiol New Haven CT USA;

NCI Lab Translat Genom Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

Johns Hopkins Sch Med Dept Oncol Sidney Kimmel Comprehens Canc Ctr Baltimore MD USA;

NCI Div Canc Epidemiol &

Genet NIH Bethesda MD 20892 USA;

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专利

1. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer [J] . Walsh Naomi, Zhang Han, Hyland Paula L., Journal of the National Cancer Institute . 2019,第6期

机译：易毒性途径/基因集分析基因组关联数据识别胰腺癌的关联
2. Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer [J] . Donghui Li, Eric J. Duell, Kai Yu, Carcinogenesis . 2012,第7期

机译：全基因组关联研究数据的途径分析突出了胰腺发育基因作为胰腺癌的易感因素
3. Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer [J] . Donghui Li†‡ Eric J. Duell1†‡ Kai Yu2†‡ Harvey A. Risch3‡ Sara H. Olson4‡ Charles Kooperberg5‡ Brian M. Wolpin67‡ Li Jiao8‡ Xiaoqun Dong‡ Bill Wheeler9‡ Alan A. Arslan101112 H. Bas Bueno-de-Mesquita1314 Charles S. Fuchs67 Steven Gallinger15 Myron Gross16 Patricia Hartge2 Robert N. Hoover2 Elizabeth A. Holly17 Eric J. Jacobs18 Alison P. Klein1920 Andrea LaCroix5 Margaret T. Mandelson521 Gloria Petersen22 Wei Zheng23 Ilir Agalliu24 Demetrius Albanes2 Marie-Christine Boutron-Ruault25 Paige M. Bracci17 Julie E. Buring2627 Federico Canzian28 Kenneth Chang29 Stephen J. Chanock23031 Michelle Cotterchio3233 J.Michael Gaziano34 Edward L. Giovannucci73536 Michael Goggins37 Göran Hallmans38 Susan E. Hankinson735 Judith A. Hoffman Bolton39 David J. Hunter735 Amy Hutchinson231 Kevin B. Jacobs23140 Mazda Jenab41 Kay-Tee Khaw42 P Carcinogenesis . 2012,第7期

机译：全基因组关联研究数据的途径分析突出了胰腺发育基因作为胰腺癌的易感因素
4. GENOME-WIDE ASSOCIATION ANALYSIS IDENTIFIES A MAJOR GENE FOR LATE MATURITY ALPHA-AMYLASE (LMA) ACTIVITY IN SYNTHETICHEXAPLOID WHEAT [C] . L.C. Emebiri, J.R. Oliver, K. Mrva, Australian cereal chemistry conference . 2010

机译：基因组 - 宽的关联分析鉴定了合成素薄液中晚期成熟α-淀粉酶（LMA）活性的主要基因
5. Pancreatic cancer risk and prevention: Association with PPARG gene and policy analysis of tobacco-related pancreatic cancer. [D] . Fesinmeyer, Megan Dann. 2007

机译：胰腺癌的风险和预防：与PPARG基因的关联以及与烟草有关的胰腺癌的政策分析。
6. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer [O] . Naomi Walsh, Han Zhang, Paula L Hyland, -1

机译：全基因组关联数据的不可知途径/基因组分析确定了胰腺癌的关联
7. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer [O] . Naomi Walsh, Han Zhang, Paula L Hyland, 2018

机译：易毒性途径/基因集分析基因组关联数据识别胰腺癌的关联

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

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