Letter: Sleep and psychological disorders in patients with inflammatory bowel diseases; Another potential role of vitamin D deficiency

摘要

Sirs, We read with great interest the comprehensive review study of Mouli and Ananthakrishnan.The authors have evaluated and discussed current evidence regarding the roles of vitamin D deficiency in the patho-genesis and progression of inflammatory bowel disease (IBD). In this regard, different cellular and molecular mechanisms are discussed in this review. However, as mentioned by the authors, there is a strong role for environmental factors in the pathogenesis and progression of IBD. There is growing evidence that psychological factors, including psychological stress and depression, are influential in the pathogenesis and clinical course of IBD. Growing evidence also indicates the importance of sleep disorders in the clinical course of IBD. It has been shown that sleep disturbance increases the risk of disease flares in patients.