Insights Into Molecular Interaction of Antitumor Drug Mitoxantrone With Anionic Surfactant Sodium Dodecyl Sulfate at Different Temperatures

摘要

A study of the interaction of antitumor drug mitoxantrone with anionic surfactant sodium dodecyl sulfate (SDS) has been carried out by UV-Vis absorption spectroscopy at submicellar and micellar surfactant concentrations, pH 7.4 and 10, and over a temperature range of 293.15-323.15 K. The variation of the monomer drug absorbance as a function of SDS concentration indicates, at pH 7.4 and all investigated temperatures, two definite processes: process I in the submicellar range, attributed to the electrostatic interaction between mitoxantrone and SDS monomers; and process II in the micellar range, when the drug is incorporated into SDS micelles in monomer form. At pH 10, the results have indicated only the process II at micellar SDS concentrations. The monomer absorbance changes occurring as a result of the interactions between mitoxantrone and SDS were rationalized in terms of binding constant, micelle/water partition coefficient, and the corresponding thermodynamic parameters for binding and partitioning processes. Thermodynamic parameters indicate that at pH 7.4 both binding process of mitoxantrone to SDS and partition process of mitoxantrone between micellar and bulk aqueous phases are spontaneous and enthalpy controlled, while at pH 10 both processes are spontaneous and entropy controlled.