A hierarchical screening method for detection of illegal adulterants in Fur seal ginseng pills by profiling analysis of HPLC multi‐dimensional fingerprints

Wang Ke; Zeng Huiyun; Zhang Yi; Xie Xiujuan; Yue Zhenfeng; Zhang Wei; Fu Chujun; Luo Laicheng; Fan Huajun

摘要

Abstract >A novel method for hierarchical screening of illegal adulterants in Fur seal ginseng pills products was developed by multi‐dimensional fingerprint profiling analysis. Fingerprint feature of the samples was acquired by high‐performance liquid chromatography analysis of 11 batches of samples with diode array detector and fluorescence detector, and then potential illegal adulterants including phosphodiesterase type‐5 inhibitors, androgens, α receptor antagonists and yohimbine, were further separated at multiple wavelengths to reduce or remove interferences from sample matrix for highlight their chromatographic characteristics. Accordingly, a hierarchical screening strategy was designed by first‐order and second‐order fingerprints combined with spectral examination to achieve high accuracy and reliability. The method was successfully applied to screening of illegal adulterants in real samples, and it also exhibited good quantification performance through validation tests. From 16 batches of samples, three suspected samples were confirmed to be positive, containing 9.37μg/g of testosterone, 18.8 μg/g of tadalafil, and 48.5 μg/g of sildenafil, respectively. The recoveries and relative standard deviations were in the range of 83.6–103.1% and 4.2–6.8%, respectively. The proposed method provided a simple, efficient and promising alternative to monitoring functional foods. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <Title Type =“main”>抽象</ title> >毛皮封印人参丸产品中非法掺杂剂的分层筛查的新方法是由多数多功能开发的 - 尺寸指纹分析分析。通过高性能液相色谱分析来获取样品的指纹特征，其11批样品具有二极管阵列检测器和荧光检测器，然后潜在的非法掺杂剂，包括磷酸二酯酶类型-5抑制剂，雄激素，α受体拮抗剂和尤韦宾等在多个波长下，减少或去除样品矩阵的干扰以突出其色谱特性。因此，通过一阶和二阶指纹设计了分层筛选策略，与光谱检查结合以实现高精度和可靠性。该方法已成功应用于筛选真实样本中的非法掺杂剂，通过验证测试也表现出良好的量化性能。从16批样品中，证实了三个可疑样品为阳性，含有9.37μg/ g的睾酮，18.8μg/ g的塔达拉非，分别为48.5μg/ g的Sildenafil。回收率和相对标准偏差分别为83.6-103.1％和4.2-6.8％。该提出的方法提供了一种简单，有效和有前途的替代方案，用于监测功能性食物。</ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2019年第8期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Ke&option=202" target="_blank" rel="nofollow">Wang Ke;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zeng Huiyun&option=202" target="_blank" rel="nofollow">Zeng Huiyun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yi&option=202" target="_blank" rel="nofollow">Zhang Yi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xie Xiujuan&option=202" target="_blank" rel="nofollow">Xie Xiujuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yue Zhenfeng&option=202" target="_blank" rel="nofollow">Yue Zhenfeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Wei&option=202" target="_blank" rel="nofollow">Zhang Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fu Chujun&option=202" target="_blank" rel="nofollow">Fu Chujun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luo Laicheng&option=202" target="_blank" rel="nofollow">Luo Laicheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fan Huajun&option=202" target="_blank" rel="nofollow">Fan Huajun;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>Food Inspection and Quarantine Technology CenterShenzhen Academy of Inspection and QuarantineShenzhen P. R. China;</p> <p>School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>Food Inspection and Quarantine Technology CenterShenzhen Academy of Inspection and QuarantineShenzhen P. R. China;</p> <p>School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> <p>School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=functional foods&option=203" rel="nofollow">functional foods;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fur seal ginseng pills&option=203" rel="nofollow">Fur seal ginseng pills;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hierarchical screening&option=203" rel="nofollow">hierarchical screening;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=illegal adulterants&option=203" rel="nofollow">illegal adulterants;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multi‐dimensional fingerprints&option=203" rel="nofollow">multi‐dimensional fingerprints;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=traditional Chinese medicine&option=203" rel="nofollow">traditional Chinese medicine;</a> </p> <div class="translation"> 机译：功能性食物;皮草封存人参丸;层次筛查;非法掺杂剂;多维指纹;中医; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div 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