首页> 外文期刊>Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology >Isolated Central Nervous System Relapse Following Treatment Reduction in Low-risk Acute Lymphoblastic Leukemia at the Children's Cancer Center of Lebanon
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Isolated Central Nervous System Relapse Following Treatment Reduction in Low-risk Acute Lymphoblastic Leukemia at the Children's Cancer Center of Lebanon

机译:在黎巴嫩儿童癌症中心的低危急性淋巴细胞白血病治疗后分离的中枢神经系统复发

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摘要

The aim of this trial was to decrease the incidence of life-threatening infections by decreasing the dose and the duration of dexamethasone treatment during maintenance therapy. This was a prospective, nonrandomized trial of low-risk acute lymphoblastic leukemia patients 1 to 18 years of age who were treated at the Children's Cancer Center of Lebanon (CCCL). Patients consecutively diagnosed between 2002 and 2013 were divided into groups 1 and 2 receiving total dexamethasone doses of 1144 and 618mg/m(2), respectively. A total of 84 patients were assigned to group 1 and 33 patients to group 2. The 5-year cumulative incidence of isolated central nervous system relapse increased from (n=0% [95% confidence interval: 0%-4.4%]) in group 1 to 9.1% [95% confidence interval: 3%-23%]; P=0.021) in group 2. Decreasing cumulative dose of dexamethasone for low-risk childhood acute lymphoblastic leukemia patients aiming to avoid serious viral infections led to a significant increase in isolated central nervous system relapse.
机译:该试验的目的是通过减少维持治疗期间通过降低地塞米松治疗的剂量和持续时间来降低危及危及危及危及终身感染的发病率。这是一项未来,非风险的低危急性淋巴细胞白血病患者1至18岁的前瞻性试验,黎巴嫩儿童癌症中心(CCCL)进行治疗。在2002和2013之间诊断患者分为1和2组,分别接受1144和618mg / m(2)的总塞米松剂量。将84名患者分配给1组和33例患者组。5年级中枢神经系统复发的5年累积发病率增加到(n = 0%[95%置信区间:0%-4.4%])第1组至9.1%[95%置信区间:3%-23%]; P = 0.021)在第2组中。降低累积的低风险儿童急性淋巴细胞白血病患者的累积剂量,旨在避免严重的病毒感染导致孤立的中枢神经系统复发显着增加。

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