Oral administration of yeast beta-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis

摘要

Ulcerative colitis is a chronic inflammatory disease that is characterized by relapsing inflammation and dysfunction within the gastrointestinal tract. The purpose of this study was to investigate the protective effects of yeast beta-glucan on regulating inflammation and disruption of the epithelial barrier in colitis caused by dextran sulfate sodium (DSS). Oral administration of yeast B-glucan reduced clinical symptoms, inflammatory infiltrates and cell apoptosis in the colon epithelium, ameliorated intestinal permeability and the structural integrity of tight junctions. Moreover, treatment with yeast B-glucan not only decreased myeloperoxidase, eosinophil peroxidase and N-acetyl-beta-D-glucosaminidase levels, but also modified the immune status characterized by the change in immunoglobulin levels in DSS-treated mice. These results suggest that yeast beta-glucan improves DSS-induced changes in mucosal inflammatory lesions and the intestinal barrier by inhibiting the expression of inflammatory mediators and enhancing the expression of tight junction proteins associated with intestinal permeability. (C) 2017 Elsevier Ltd. All rights reserved.