The Chemistry of Acetylpyrazoles and Its Utility in Heterocyclic Synthesis

摘要

A literature survey revealed that a great deal of interest has been focused on the synthesis of functionalized pyrazole derivatives due to their synthetic and biological potentialities. The pharmacological activities that have been found for some pyrazole derivatives include selective enzyme inhibition, antiviral, estrogen receptor agonist, anti-inflammatory, anticancer, antiobesity, and antitumor properties. Other activities such as potential inhibitors of HIV-1, pesticides, fungicides, and antihypertensive agents were reported for other pyrazole derivatives. This review summarizes the synthetic methods and reactions of 3-acetyl-pyrazoles, 4-acetyl-pyrazoles, and 3,4-di-acetyl-pyrazoles. Most reaction types have been successfully applied and used in the production of biologically active compounds. The aim of this review is to focus mainly on the utility of acetylpyrazole derivatives in the synthesis of heterocyclic compounds during the period 1990-2018.