A novel method to efficiently isolate medullary thymic epithelial cells from murine thymi based on UEA-1 MicroBeads

摘要

Objective: The central mechanism for establishing a self-tolerant and functional T cell repertoire includes the promiscuous expression of otherwise tissue-restricted proteins by medullary thymic epithelial cells (TEC). We here demonstrate a novel and highly efficient method for isolating this rare key cell type.