AMPK alpha 1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression

摘要

Background: AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status that contributes to restoration of energy homeostasis by slowing down ATP-consuming pathways and activating ATP-producing pathways. Unexpectedly, in different systems, AMPK is also required for proper cell division. In the current study, we evaluated the potential effect of the AMPK catalytic subunit, AMPK alpha 1, on hepatocyte proliferation.