1,2-(hydr)oxy-trifluoromethylation of C-C multiple bonds: Synthesis of beta-trifluoromethyl alcohols and alpha-trifluoromethyl ketones

摘要

Difunctionalizing trifluoromethylation of carbon-carbon multiple bonds has recently developed into a robust tool for preparation of complex CF3-functionalized molecules without pre-functionalization of starting materials. In this context, 1,2-(hydr)oxy-trifluoromethylation of alkenes and alkynes has gained increasing interest since it enables the facile and rapid fabrication of biologically and synthetically important beta-trifluoromethyl alcohols and alpha-trifluoromethyl ketones from easily accessible starting materials within a single click. The objective of this review is to summarize the available literature on this appealing and fast-growing research arena. Mechanistic features of the reactions are considered and discussed in detail which may allow possible new insights into catalyst improvement.