STUDIES ON EVALUATION OF ANTIDIABETIC EFFICACY OF AQUEOUS EXTRACT OF murraya koenigiiIN STREPTOZOTOCIN INDUCEDDIABETIC RATS

摘要

Antidiabetic efficacy of aqueous extract of Murraya koenigii leaves was evaluated in streptozotocin induced diabetic rats. Streptozotocin at the dose rate of 40 mg/kg was used to induce diabetes experimentally in Wister albino female rats. The variousgroups in this study included Normal Control (Group I), Diabetic Control (Group IT), Diabetic rats treated with Glibenclamide at the dose of600 ug/kg (Group in), Diabetic rats treated with Murraya koenigii at the dose of300 mg/kg (Group IV) and Diabeticrats treated with combination of Murraya koenigii (150 mg/kg) and Glibenclamide (300 ug/kg) (Group V). Diabetes was confirmed by estimating the serum glucose levels 72 hours post STZ injection. At various intervals the serum samples were collected fromthe rats and subjected for the estimation of glucose by using biochemical analyzer. The serum glucose values in diabetic control rats were significantly higher (P< 0.001) at all the intervals of study in comparison with normal control rats. The mean (±SE) serum glucose levels in the diabetic rats treated with Glibenclamide at the dose of 600 ug/kg body weight showed a gradual reduction from 3rd to 45th day when compared to diabetic control rats. Gradual decrease in the mean (± SE) serum glucose values in the diabetic rats treated with Murraya koenigii individually and in combination with Glibenclamide was noticed. The combined treatment of Murraya koenigii (150 mg/kg) with Glibenclamide (300 ug /kg) revealed better antidiabetic efficacy, which indicated a synergistic effect of Murraya koenigii and Glibenclamide when used in combination.