Protective effects of a novel nutritional and phytonutrient blend on ultraviolet radiation‐induced skin damage and inflammatory response through aging defense mechanisms

摘要

Summary Background The human body relies on several aging defense mechanisms ( ADM s) to limit damage induced from pro‐aging stressors (aging aggressors). However, such protective mechanisms can be compromised, leading to accelerated aging. The skin provides a model to probe the effects of an oral nutritional intervention on ADM s in response to ultraviolet radiation ( UVR )‐induced damage. Objective To determine whether supplementation with a novel nutritional and phytonutrient blend could protect against UVR ‐induced skin damage and positively influence facial skin attributes and characteristics by bolstering ADM s. Methods Thirty‐six healthy, nonsmoking women (40–75 years) with Fitzpatrick skin types I and II were recruited. UVR ‐induced erythema and the number of apoptotic cells were determined before (pre‐) and after 8‐week (post‐) supplementation. Other clinical variables included skin carotenoid concentrations, facial skin attributes and characteristics. Results Eight‐week supplementation led to protection against UVR ‐induced skin damage as evidenced by reductions in erythema at all three minimal erythema doses ( MED s) (9.1 to 7.4 [ P = 0.10]; 15.8 to 13.6 [ P = 0.02]; and 19.6 to 17.3 [ P = 0.01] for one, two, and three MED s and a reduction in the average number of apoptotic cells [11.3 to 5.3, P 0.0001] pre‐ and post‐supplementation, respectively). Skin carotenoid concentrations increased from 28 111 Raman intensity units to 38 472 ( P 0.0001) along with noticeable improvements in facial skin attributes and characteristics: elasticity, transepidermal water loss, radiance, texture, and overall appearance (all P 0.05) following supplementation. Conclusion Eight weeks of oral supplementation positively impacted ADM s resulting in protection against UVR ‐induced skin damage and improvements in facial skin attributes and characteristics.