Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

Monirinasab Hannaneh; Asadi Hamed; Rostamizadeh Kobra; Esmaeilzadeh Abdolreza; Khodaei Malihe; Fathi Mojtaba

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Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

机译：用于乳腺癌细胞中的siRNA递送和IGF-1R基因的新型脂质 - 聚合物杂交纳米颗粒

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Background: Delivery of siRNA has been one of the major challenges to application of siRNA therapeutics. Polymer/lipid hybrid nanoparticles (HNPs) combine the advantages of both polymeric and liposomal carriers with remarkable properties for efficient siRNA encapsulation and delivery.

机译：背景：siRNA的递送是应用siRNA治疗方法的主要挑战之一。聚合物/脂质杂化纳米颗粒（HNP）结合了聚合物和脂质体载体的优点，具有显着性的性能，以获得有效的siRNA封装和递送。

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《Journal of drug delivery science and technology》 |2018年第2018期|共10页
作者
Monirinasab Hannaneh; Asadi Hamed; Rostamizadeh Kobra; Esmaeilzadeh Abdolreza; Khodaei Malihe; Fathi Mojtaba;
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作者单位

Zanjan Univ Med Sci Sch Med Dept Clin Biochem Zanjan Iran;

Univ Tehran Sch Sci Chem Dept Polymer Lab Tehran Iran;

Zanjan Univ Med Sci Sch Pharm Dept Med Chem Zanjan Iran;

Zanjan Univ Med Sci Fac Med Dept Immunol Zanjan Iran;

Zanjan Univ Med Sci Sch Med Dept Med Biotechnol Zanjan Iran;

Zanjan Univ Med Sci Sch Med Dept Clin Biochem Zanjan Iran;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Lipid-polymer hybrid nanoparticles; siRNA delivery; PLA-PEG-PLA tri-block copolymer; Gene silencing; Cancer therapy;

机译：脂质聚合物杂交纳米颗粒;siRNA递送;PLA-PEG-PLA三嵌段共聚物;基因沉默;癌症治疗;

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专利

1. Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells [J] . Monirinasab Hannaneh, Asadi Hamed, Rostamizadeh Kobra, Journal of drug delivery science and technology . 2018,第期

机译：用于乳腺癌细胞中的siRNA递送和IGF-1R基因的新型脂质 - 聚合物杂交纳米颗粒
2. Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells [J] . Materials science & engineering . 2020,第Apra期

机译：多功能杂化纳米粒子作为靶向HER2基因的siRNA在乳腺癌细胞中的磁性传递系统
3. Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells [J] . Cristofolini Tatiane, Dalmina Milene, Sierra Jelver A., Materials science & engineering, C. Materials for Biogical applications . 2020,第期

机译：多功能杂交纳米粒子作为靶向乳腺癌细胞中HER2基因的siRNA的磁输送系统
4. Carbon nanotube-mediated siRNA delivery for gene silencing in cancer cells [C] . Tu Hong, Honglian Guo, Yaqiong Xu Biosensing and nanomedicine IV . 2011

机译：碳纳米管介导的siRNA传递可实现癌细胞基因沉默
5. Evaluation of therapeutic effect of IKK epsilon siRNA on breast cancer cells and development of a peptide-based siRNA delivery system [D] . Qin, Bin 2012

机译：评估IKK epsilon siRNA对乳腺癌细胞的治疗效果以及基于肽的siRNA递送系统的开发
6. Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs [O] . Yong Tsuey Li, Ming Jang Chua, Anil Philip Kunnath, 2012

机译：通过沉默ABC转运蛋白基因与纳米粒子促进靶siRNA的传递来逆转乳腺癌细胞的多药耐药性
7. Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs [O] . Li, Yong Tsuey, Chua, Ming Jang, Kunnath, Anil Philip, 2012

机译：通过沉默ABC转运蛋白基因与纳米粒子促进靶siRNA的传递来逆转乳腺癌细胞的多药耐药性

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

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