Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis

Church Peter C.; Ho Shaun; Sharma Ajay; Tomalty Diane; Frost Karen; Muise Aleixo; Walters Thomas D.; Griffiths Anne M.

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Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis

机译：强化英夫利昔单抗诱导与类固醇难治性儿科溃疡性结肠炎的响应改善和脱髓鞘降低有关

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Background Infliximab pharmacokinetics in steroid-refractory [SR] ulcerative colitis [UC] suggest a need for higher dosing, but data concerning efficacy of intensification in this setting are lacking in children and inconsistent overall.

机译：背景技术类固醇难治性[SR]溃疡性结肠炎的intiximab药代动力学表明需要更高的给药，但是缺乏儿童的增强效能的数据和整体不一致。

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《Journal of Crohn’s & colitis》 |2019年第8期|共8页
作者
Church Peter C.; Ho Shaun; Sharma Ajay; Tomalty Diane; Frost Karen; Muise Aleixo; Walters Thomas D.; Griffiths Anne M.;
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作者单位

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

Univ Toronto Dept Paediat Div Gastroenterol Hepatol &

Nutr Toronto ON Canada;

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原文格式 PDF
正文语种 eng
中图分类杆菌传染病;
关键词
Infliximab; ulcerative colitis; paediatric;

机译：英夫利昔单抗;溃疡性结肠炎;儿科;

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专利

1. Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis [J] . Church Peter C., Ho Shaun, Sharma Ajay, Journal of Crohn’s & colitis . 2019,第8期

机译：强化英夫利昔单抗诱导与类固醇难治性儿科溃疡性结肠炎的响应改善和脱髓鞘降低有关
2. Response to: Infliximab three-dose induction regimen in severe corticosteroid-refractory ulcerative colitis: Early and late outcome and predictors of colectomy [J] . TungJ., EndersF.T., LoftusE.V. Journal of Crohn’s & colitis . 2014,第10期

机译：回应：英夫利昔单抗三剂量诱导方案治疗严重皮质类固醇难治性溃疡性结肠炎：早期和晚期结果及结肠切除术的预测指标
3. Early colectomy in steroid-refractory acute severe ulcerative colitis improves operative outcome [J] . Saha Sujeet Kumar, Panwar Rajesh, Kumar Ameet, International journal of colorectal disease. . 2018,第1期

机译：类固醇难治性急性严重溃疡性结肠炎的早期联合膜改善了操作结果
4. Azathioprine in the treatment of paediatric ulcerative colitis [C] . H. K. HARMS, M. KAPPLER, R. M. BERTELE-HARMS Falk Symposium . 2002

机译：Azathioprine治疗小儿溃疡性结肠炎
5. Nanostructured Surface Modifications to Decrease Infection and Improve Bone Cell Responses on Orthopedic Biomaterials. [D] . Hickey, Daniel James. 2016

机译：纳米结构表面修饰可减少感染并改善骨科生物材料上的骨细胞反应。
6. Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study [O] . Laurent Peyrin-Biroulet, Cécile Laclotte, Xavier Roblin, 2007

机译：阿达木单抗诱导疗法治疗不耐受或对英夫利昔单抗失去反应的溃疡性结肠炎：一项开放性研究
7. P495 Intensified infliximab rescue therapy for acute severe ulcerative colitis does not improve long term colectomy-free survival [O] . A. Al Khoury, C.-y. Chao, A. Aruljothy, 2017

机译：P495强化急性严重溃疡性结肠炎的英夫利昔单抗救援治疗并未改善无长期的联合肌瘤生存

Intensified Infliximab Induction is Associated with Improved Response and Decreased Colectomy in Steroid-Refractory Paediatric Ulcerative Colitis

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