Current challenges in second-order calibration of hyphenated chromatographic data for analysis of highly complex samples

摘要

Coupling of multiway and multiset modeling methods with hyphenated chromatographic data for second-order calibration allows the quantification of analytes in highly complex samples. In this regard, there are some chromatographic challenges that complicate attaining the required efficiency through the advantages such as increased sensitivity and selectivity and the second-order advantage. The present paper tries to overview these issues and to address the most usable strategies for their handling with a special focus on the relevant recent studies in quantitation field.