Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

Ueda Takuya; Aokage Keiju; Nishikawa Hiroyoshi; Neri Shinya; Nakamura Hiroshi; Sugano Masato; Tane Kenta; Miyoshi Tomohiro; Kojima Motohiro; Fujii Satoshi; Kuwata Takeshi; Ochiai Atsushi; Kusumoto Masahiko; Suzuki Kenji; Tsuboi Masahiro; Ishii Genichiro

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Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

机译：免疫抑制肿瘤微环境常绿肺炎相关的肺部相关鳞状细胞癌

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Purpose Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).

机译：目的患者常用的间质肺炎（UIP）经常发展肺癌。然而，与UIP相关的肺癌的生物学特征仍然未知。本研究的目的是阐明UIP相关鳞状细胞癌（SQCC）的临床病理特征。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2018年第5期|共10页
作者
Ueda Takuya; Aokage Keiju; Nishikawa Hiroyoshi; Neri Shinya; Nakamura Hiroshi; Sugano Masato; Tane Kenta; Miyoshi Tomohiro; Kojima Motohiro; Fujii Satoshi; Kuwata Takeshi; Ochiai Atsushi; Kusumoto Masahiko; Suzuki Kenji; Tsuboi Masahiro; Ishii Genichiro;
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作者单位

Natl Canc Ctr Div Pathol Exploratory Oncol Res &

Clin Trial Ctr 6-5-1 Kashiwanoha Kashiwa;

Natl Canc Ctr Hosp East Dept Thorac Surg Kashiwa Chiba Japan;

Natl Canc Ctr Div Canc Immunol Exploratory Oncol Res &

Clin Trial Ctr Kashiwa Chiba Japan;

Kyoto Univ Grad Sch Med Dept Thorac Surg Kyoto Japan;

Natl Canc Ctr Div Pathol Exploratory Oncol Res &

Clin Trial Ctr 6-5-1 Kashiwanoha Kashiwa;

Natl Canc Ctr Hosp East Dept Pathol Kashiwa Chiba Japan;

Natl Canc Ctr Hosp East Dept Thorac Surg Kashiwa Chiba Japan;

Natl Canc Ctr Hosp East Dept Thorac Surg Kashiwa Chiba Japan;

Natl Canc Ctr Div Pathol Exploratory Oncol Res &

Clin Trial Ctr 6-5-1 Kashiwanoha Kashiwa;

Natl Canc Ctr Div Pathol Exploratory Oncol Res &

Clin Trial Ctr 6-5-1 Kashiwanoha Kashiwa;

Natl Canc Ctr Hosp East Dept Pathol Kashiwa Chiba Japan;

Natl Canc Ctr Exploratory Oncol Res &

Clin Trial Ctr Kashiwa Chiba Japan;

Natl Canc Ctr Hosp East Dept Diagnost Radiol Chiba Japan;

Juntendo Univ Sch Med Dept Gen Thorac Surg Tokyo Japan;

Natl Canc Ctr Hosp East Dept Thorac Surg Kashiwa Chiba Japan;

Natl Canc Ctr Div Pathol Exploratory Oncol Res &

Clin Trial Ctr 6-5-1 Kashiwanoha Kashiwa;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Lung squamous cell carcinoma; Usual interstitial pneumonia; PD-L1; Tumor immunity; Tumor microenvironment;

机译：肺鳞状细胞癌;常春性肺炎;PD-L1;肿瘤免疫;肿瘤微环境;

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专利

1. Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung [J] . Ueda Takuya, Aokage Keiju, Nishikawa Hiroyoshi, Journal of Cancer Research and Clinical Oncology . 2018,第5期

机译：免疫抑制肿瘤微环境常绿肺炎相关的肺部相关鳞状细胞癌
2. Identification of the key genes and characterizations of Tumor Immune Microenvironment in Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LUSC) [J] . Lemeng Zhang, Jianhua Chen, Tianli Cheng, Journal of Cancer . 2020,第17期

机译：肿瘤免疫微环境对肺腺癌（鹿达）和肺鳞状细胞癌（LUSC）的关键基因及其特征
3. Effect of Lung Squamous Cell Carcinoma Tumor Microenvironment on the CD105+ Endothelial Cell Proteome [J] . Huiqin Zhuo, Zhi Lyu, Jing Su, Journal of proteome research . 2014,第11期

机译：肺鳞状细胞癌肿瘤微环境对CD105 +内皮细胞蛋白质组的影响
4. Genome-wide DNA methylation analysis in tumor and normal tissues from lung squamous cell carcinoma and serous cystadenocarcinoma [C] . 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops . 2010

机译：肺鳞状细胞癌和浆液性囊腺癌的肿瘤和正常组织中全基因组DNA甲基化分析
5. Gene expression analysis of human non -small cell lung cancer subtypes, adenocarcinoma and squamous cell carcinoma, and mouse lung epithelial cell lines: Implications in lung tumorigenesis [D] . Silvers, Amy Lynn. 2002

机译：人类非小细胞肺癌亚型，腺癌和鳞状细胞癌以及小鼠肺上皮细胞系的基因表达分析：在肺肿瘤发生中的意义
6. Four hub genes regulate tumor infiltration by immune cells antitumor immunity in the tumor microenvironment and survival outcomes in lung squamous cell carcinoma patients [O] . Tuo Zhang, Haitang Yang, Beibei Sun, 2021

机译：四个枢纽基因通过免疫细胞肿瘤微环境中的抗肿瘤免疫力调节肿瘤浸润以及肺鳞状细胞癌患者的存活结果
7. Prognostic value of immune-related genes in the tumor microenvironment of lung adenocarcinoma and lung squamous cell carcinoma [O] . Yan Qu, Bo Cheng, Na Shao, 2020

机译：免疫相关基因在肺腺癌和肺鳞状细胞癌肿瘤微环境中的预后价值

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

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