Sleep-Wake Cycle in Alzheimer's Disease Is Associated with Tau Pathology and Orexin Dysregulation

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Sleep-Wake Cycle in Alzheimer's Disease Is Associated with Tau Pathology and Orexin Dysregulation

机译：阿尔茨海默病的睡眠循环与TAU病理学和orexin的失调相关联

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Background: Alzheimer's disease (AD) is the most common form of dementia. It is mainly characterized by a progressive deterioration of cognition, but sleep-wake cycle disturbances frequently occur. Irregular sleep-wake cycle, insomnia, and daytime napping usually occur in patients with AD in the course of the disease.

机译：背景：阿尔茨海默病（AD）是最常见的痴呆形式。它主要是对认知的逐步恶化，但经常发生睡眠唤醒循环障碍。在疾病过程中，AD患者通常发生不规则的睡眠循环，失眠和白天射击。

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《Journal of Alzheimer's disease: JAD》 |2020年第2期|共8页
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Alzheimer's disease; cognition; orexin; sleep-wake cycle; tau proteins;

机译：阿尔茨海默病;认知;orexin;睡眠尾循环;tau蛋白;

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1. Sleep-Wake Cycle in Alzheimer's Disease Is Associated with Tau Pathology and Orexin Dysregulation [J] . Journal of Alzheimer's disease: JAD . 2020,第2期

机译：阿尔茨海默病的睡眠循环与TAU病理学和orexin的失调相关联
2. Distinct Chronology of Neuronal Cell Cycle Re-Entry and Tau Pathology in the 3xTg-AD Mouse Model and Alzheimer's Disease Patients [J] . Hradek Alex C., Lee Hyun-Pil, Siedlak Sandra L., Journal of Alzheimer's disease: JAD . 2015,第1期

机译：在3xTg-AD小鼠模型和阿尔茨海默氏病患者中神经元细胞周期重新进入和Tau病理的不同年代学
3. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer's disease pathogenesis [J] . HoY.-S., YangX., LauJ.C.-F., Journal of Alzheimer's disease: JAD . 2012,第4期

机译：内质网应激诱发tau病理并形成恶性循环：对阿尔茨海默氏病发病机制的影响
4. INVESTIGATING TAU PATHOLOGY AND THE ASSOCIATED MICROTUBULIN INSTABILITY IN AN IN VITRO MODEL FOR ALZHEIMER'S DISEASE [C] . Y. S. L. Powrie, B. Loos Annual Conference of the Microscopy Society of Southern Africa . 2016

机译：调查TAU病理学和Alzheimer疾病体外模型中的相关微管蛋白不稳定性
5. Characterizing Alzheimer’s Disease Pathology and Molecular Signaling Dysregulation in Aged Cynomolgus Macaques with Normal and High Blood Glucose [D] . Jester, Hannah M. 2020

机译：用正常和高血糖表征阿尔茨海默病病理学和分子信令缺血剂，血清瘤猕猴血糖
6. Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3×Tg-AD mouse model and Alzheimer disease patients [O] . Alex C. Hradek, Hyun-Pil Lee, Sandra L. Siedlak, -1

机译：在3×Tg-AD小鼠模型和阿尔茨海默氏病患者中神经元细胞周期再进入和tau病理的明显年代学
7. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer's disease pathogenesis [O] . Wuwongse S, Ho YS, Yang X, 2012

机译：内质网应激诱导tau病理并形成恶性循环：阿尔茨海默病发病机制的意义

Sleep-Wake Cycle in Alzheimer's Disease Is Associated with Tau Pathology and Orexin Dysregulation

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