Redox-responsive hollow mesoporous silica nanoparticles constructed via host-guest interactions for controllable drug release

摘要

A novel redox-responsive hollow mesoporous silica (HMS) was constructed by host-guest interaction between beta-cyclodextrin modified hollow mesoporus silica nanoparticles (HMS@beta-CD) and the ferrocene-containing amphiphilic block copolymer PEG-b-PMAFc (PPFc), the prepared HMS@beta-CD@PPFc system was used to control drug delivery in targeted cancer therapy through redox stimulus. The self-assembled morphology was investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Intracellular localization of DOX-loaded HMS@beta-CD@PPFc in A549 cells was further investigated by confocal laser scanning microscopy (CLSM), and the results indicated that DOX-loaded HMS@beta-CD@PPFc was ingested by A549 cells effectively. Furthermore, the redox agent H2O2 was used to trigger the release of DOX. The cytotoxicity evaluated by MTT method indicated that HMS@beta-CD@PPFc had good biocompatibility and was promising as the drug carrier.