Hepatoprotective and Nephroprotective Effects of Garcinia kola Heckel Stem Bark Extract and Triterpenoid Fraction Against Sodium Arsenite-Induced Toxicity in Rat Models

摘要

Garcinia kola Heckel (Clusiaceae) has been widely used in ethnomedicine practice as a therapy against numerous disorders. Therefore, this study wts designed to evaluate the protective effects of orally administered G kola stem bark ethanolic extract (EEGK) and triterpenoid fraction (TFGK) against sodium arsenite-in.iuced hepatotoxicity and nephrotoxicity using rat code's for 14 days. Assays for plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), totalbilirubin, urea, and creatinine, liver, kidney, and plasma superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) activities were carried out using spectrophotoinetric methods. Gas chromatography-mass spectrometry analytical method was used to identity the bioactive compounds present in TFGK and EEGK, Hematological parameters were assayed using autoanalyzer. Data showed that TFGK reduced liver function markers viz. ALT, AST, ALP, and total bilirubin, vvhile EEGK reduced kidney function markers viz. plasma creatinine and urea. Furthermore, EEGK elevated plasma, liver and kidney SOD, GPx, and GSH while TFGK modulated hematological markers. F ladings from this study showed that TFGK substantially protected against sodium arsenite-mduced hepatotoxicity while EEGK.protected against jodium arsco ite-induced nephrotoxicity.