From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3

摘要

AbstractThe mitochondrial UPR (UPRmt) is rapidly gaining attention. While most studies on the UPRmthave focused on its role in aging, emerging studies suggest an important role of the UPRmtin cancer. Further, several of the players of the UPRmtin mammalian cells have well reported roles in the maintenance of the organelle. The goal of this review is to emphasize aspects of the UPRmtthat have been overlooked in the current literature, describe the role of specific players of the UPRmtin the biology of the mitochondria and highlight the intriguing possibility that targeting the UPRmtin cancer may be already within reach.]]>