Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

Sun Chunyan; Xiao Xiao; Yan Li; Sheng Li; Wang Qixia; Jiang Pan; Lian Min; Li Yanmei; Wei Yiran; Zhang Jun; Chen Yong; Li Bo; Li You; Huang Binyuan; Li Yikang; Peng Yanshen; Chen Xiaoyu; Fang Jingyuan; Qiu Dekai; Hua Jing; Tang Ruqi; Leung Patrick; Gershwin M. Eric; Miao Qi; Ma Xiong

首页> 外文期刊>Journal of Autoimmunity >Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

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Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

机译：组织学验证的AMA阳性原发性胆管炎，但正常的血清碱性磷酸酶：碱性磷酸酶真正替代标记吗？

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摘要

Background and aims: The most highly directed and specific autoantibody in human immunopathology is the serologic hallmark of primary biliary cholangitis (PBC), antimitochondrial antibodies (AMAs). However the clinical significance of finding a positive AMA, with normal alkaline phosphatase (ALP) remains enigmatic.

机译：背景和目标：人类免疫病理学中最具指向和特异性的自身抗体是原代胆管炎（PBC）的血清态标志，抗度抗体抗体（AMAs）。然而，用正常的碱性磷酸酶（ALP）找到阳性AMA的临床意义仍然是神秘的。

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来源
《Journal of Autoimmunity》 |2019年第2019期|共6页
作者
Sun Chunyan; Xiao Xiao; Yan Li; Sheng Li; Wang Qixia; Jiang Pan; Lian Min; Li Yanmei; Wei Yiran; Zhang Jun; Chen Yong; Li Bo; Li You; Huang Binyuan; Li Yikang; Peng Yanshen; Chen Xiaoyu; Fang Jingyuan; Qiu Dekai; Hua Jing; Tang Ruqi; Leung Patrick; Gershwin M. Eric; Miao Qi; Ma Xiong;
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作者单位

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Univ Calif Davis Sch Med Dept Internal Med Div Rheumatol Allergy &

Clin Immunol 451 Hlth Sci Dr;

Univ Calif Davis Sch Med Dept Internal Med Div Rheumatol Allergy &

Clin Immunol 451 Hlth Sci Dr;

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

Shanghai Jiao Tong Univ State Key Lab Oncogenes &

Related Genes Shanghai Key Lab Gastroenterol &

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Antimitochondrial antibody; Alkaline phosphatase; Histology; Cholangitis activity; Primary biliary cholangitis;

机译：抗分炎抗体;碱性磷酸酶;组织学;胆管炎活动;原发性胆管炎;

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专利

1. Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker? [J] . Sun Chunyan, Xiao Xiao, Yan Li, Journal of Autoimmunity . 2019,第期

机译：组织学验证的AMA阳性原发性胆管炎，但正常的血清碱性磷酸酶：碱性磷酸酶真正替代标记吗？
2. The resurgence of serum alkaline phosphatase as a surrogate biomarker for prognosis in primary sclerosing cholangitis [J] . TalwalkarJ.A., ChapmanR.W. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2013,第7期

机译：血清碱性磷酸酶恢复作为原发性硬化性胆管炎预后的替代生物标志物
3. Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase [J] . The American Journal of Gastroenterology . 2020,第7期

机译：治疗的进球改善原发性胆管炎的生存期：治疗靶标应在正常范围内胆红素和碱性磷酸酶的标准化
4. Prognostic significance of serum alkaline phosphatase in caniine osteosarcoma [C] . Caroline K. Garzotto, John Berg, William M. Rand, Annual Veterinary Medical Forum . 2000

机译：血清碱性磷酸酶在CANIINE骨肉瘤中的预后意义
5. Effects of Milk-Flavoring Constituents on the Fluorometric Assay of Bovine Alkaline Phosphatase [D] . Brock, Elizabeth. 2017

机译：牛奶调味组分对牛碱性磷酸酶荧光测定的影响
6. Primary Biliary Cirrhosis with a normal Alkaline Phosphatase: a case report [O] . Joshua M Brostoff, Sukaina Rashid, Daniel McCrea 2008

机译：碱性磷酸酶正常的原发性胆汁性肝硬化：一例报告
7. Editorial: further evidence for the role of serum alkaline phosphatase as a useful surrogate marker of prognosis in PSC. [O] . Williamson, KD, Chapman, RW 2015

机译：社论：血清碱性磷酸酶作为PSC预后的有用替代指标的作用的进一步证据。

Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

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