Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42998 Individuals A Meta-analysis

摘要

Question Do genetic factors underlie the association between childhood psychopathology and adult mood disorders and associated traits? Findings This meta-analysis of longitudinal cohorts, which includes data on 42998 participants, revealed significant associations between childhood psychopathology and adult polygenic scores of major depression, subjective well-being, neuroticism, insomnia, educational attainment, and body mass index but not bipolar disorder. Meaning Per this analysis, shared genetic factors exist between childhood psychopathology traits from age 6 years onwards and adult depression and associated traits.