MULTIGRAM-SCALE AND COLUMN CHROMATOGRAPHY-FREE SYNTHESIS OF L-AZETIDINE-2-CARBOXYLIC ACID FOR THE SYNTHESIS OF NICOTIANAMINE AND ITS DERIVATIVES

摘要

Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.