A SHORT SYNTHESIS OF 2,3,5-TRISUBSTITUTED PYRROLES BY AN ALKYLATION/DEHYDROCYANATION SEQUENCE

摘要

2,3,5-Trisubstituted pyrroles were prepared in a one-pot procedure from readily available 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles by an alkylation/dehydrocyanation sequence. The method was also applied to a,co-dihaloalkanes to furnish dipyrroles tethered with an alkyl spacer.