SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME NOVEL FUSED PYRIMIDO[1,2-b][1,2,4]TRIAZINE, TRIAZINO[2,3-a]QUINAZOLINE AND IMIDAZO[1,2-b][1,2,4]TRIAZINE DERIVATIVES

摘要

A novel pyrimido[1,2-b][1,2,4]triazine derivatives were synthesized by allowing 3-amino-1,2,4-triazine (1) to react with different reagents such as enaminone, enaminonitriles, 3-bromopropanenitile, 2-(2,5-dimethoxybenzylidene)malononitrile and 1,3-dicarbonyl compounds. Moreover, triazino[2,3-a]quinazoline derivatives were synthesized by reaction of 1 with 2-((dimethylamino)methylene)-5,5-dimethylcyclohexane-1,3-dione (18) and 2,6-bis(pyridin-3-ylmethylene)cyclohexan-1-one (20). On the other hand, treatment of 1 with 2-bromo-1-(naphtho[2,1-b]furan-2-yl)ethan-1-one (22) afforded imidazo[1,2-b][1,2,4]triazine derivative (23). The newly synthesized compounds were evaluated for their antimicrobial activities based on inhibition diameter zone against Gram positive and Gram negative bacteria.