SYNTHESIS OF IODINATED THIAZOLO[2,3-a]ISOQUINOLINIUM SALTS AND THEIR CRYSTAL STRUCTURES WITH/WITHOUT HALOGEN BOND

摘要

We investigated the cyclization reaction of 2-(2-(phenylethynyl)-phenyl)thiazoles with I-2. A six-membered ring was formed to produce the corresponding thiazolo[2,3-alpha]isoquinolin-7-ium salts. The counter anions (I- and I-3(-)) varied based on the structure of the thiazole moiety. We also revealed the single-crystal X-ray structures of those thiazolo[2,3-alpha]isoquinolin-7-ium salts. We discovered that various structures with and without halogen bonds existed, although they were the prospective structures to make "charge-assisted halogen bonds".