CONCISE APPROACH TO MONO- AND DISUBSTITUTED LUOTONIN A ANALOGS AND THEIR CYTOTOXICITY TEST

摘要

A concise approach for the preparation of luotonin A analogs has been developed. The new synthetic route contains an anion-assisted intramolecular double hetero Diels-Alder reaction and a direct oxidative cross coupling reaction. Some synthetic luotonin A analogs show cytotoxic activities against Daudi and Jurkat human cancer cells as potent as camptothecin.