SEMISYNTHESIS OF TRIPTOLIDE ANALOGUES PART IV: EFFECTS OF C-14 CARBAMOTHIOATE SUBSTITUENTS ON CYTOTOXIC ACTIVITIES

摘要

Four C-14 carbamothioate triptolide analogues were prepared and their cytotoxic activities on A549 human lung tumor cells and HT29 human colon tumor cells were evaluated. The activities of the prepared compounds were weaker than those of the parent compound, triptolide (1). However, some differences were noted in the activities of prepared compounds. The leaving ability and bulkiness of the amine components of their carbamothioate groups appeared to affect their cytotoxic activities.