CHEMOSELECTIVE DISPLACEMENT OF METHYLSULFTNYL GROUP WITH AMINES TO PROVIDE 2-ALKYLAMINO-4,6-DISUBSTITUTED PYRIMIDINE-5-CARBOXYLIC ACID

摘要

An efficient and rapid method for introducing various kinds of alkylamines at C2 of methyl6-(benzylamino)-4-chloro-2-(methylsulfinyl)pyrimidine-5-carboxylate using the chemoselective displacement of the methylsulfinyl group (SOMe) against a chlorine atom with amines was investigated. Further transformation led to the synthesis of 2-alkylamino-4,6-disubstituted pyrimidine-5-carboxylic acids that are of biological interest.