Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial

Worm Margitta; Simpson Eric L.; Thaci Diamant; Bissonnette Robert; Lacour Jean-Philippe; Beissert Stefan; Kawashima Makoto; Ferrandiz Carlos; Smith Catherine H.; Beck Lisa A.; Chan Kuo-Chen; Chen Zhen; Akinlade Bolanle; Hultsch Thomas; Staudinger Heribert; Gadkari Abhijit; Eckert Laurent; Davis John D.; Rajadhyaksha Manoj; Graham Neil M. H.; Pirozzi Gianluca; Stahl Neil; Yancopoulos George D.; Ardeleanu Marius

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Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial

机译：特应性皮炎患者初始成功治疗后多发性杜氏菌菌剂量方案的疗效和安全性

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摘要

This randomized clinical trial of patients previously treated with dupilumab for atopic dermatitis assesses the efficacy of different dupilumab regimens in maintaining response after 16 weeks of initial treatment.

机译：此类随机临床试验，以前用Dupilumab用于特应性皮炎的患者评估了不同Dupilumab方案在初始治疗16周后保持反应的疗效。

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来源
《JAMA dermatology》 |2020年第2期|共13页
作者
Worm Margitta; Simpson Eric L.; Thaci Diamant; Bissonnette Robert; Lacour Jean-Philippe; Beissert Stefan; Kawashima Makoto; Ferrandiz Carlos; Smith Catherine H.; Beck Lisa A.; Chan Kuo-Chen; Chen Zhen; Akinlade Bolanle; Hultsch Thomas; Staudinger Heribert; Gadkari Abhijit; Eckert Laurent; Davis John D.; Rajadhyaksha Manoj; Graham Neil M. H.; Pirozzi Gianluca; Stahl Neil; Yancopoulos George D.; Ardeleanu Marius;
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作者单位

Charite Univ Med Berlin Klin Dermatol Venerol &

Allergol Div Allergy &

Immunol Berlin Berlin;

Oregon Hlth &

Sci Univ Dept Dermatol Portland OR 97201 USA;

Univ Lubeck Inst &

Comprehens Ctr Inflammat Med Lubeck Germany;

Innovaderm Res Montreal PQ Canada;

Nice Univ Hosp Dept Dermatol Nice France;

Tech Univ Dresden Univ Klinikum Dermatol Klin &

Poliklin Dresden Germany;

Tokyo Womens Med Univ Sch Med Tokyo Japan;

Univ Autonoma Barcelona Serv Dermatol Hosp Univ Germans Trias &

Pujol Badalona Spain;

Kings Coll London St Johns Inst Dermatol Guys &

St Thomas Fdn Trust London England;

Univ Rochester Med Ctr Dept Dermatol Rochester NY 14642 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Sanofi Genzyme Cambridge MA USA;

Sanofi Bridgewater NJ USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Sanofi Chilly Mazarin France;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Sanofi Bridgewater NJ USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

Regeneron Pharmaceut Inc 777 Old Saw Mill River Rd Tarrytown NY 10591 USA;

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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
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1. Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial [J] . Worm Margitta, Simpson Eric L., Thaci Diamant, JAMA dermatology . 2020,第2期

机译：特应性皮炎患者初始成功治疗后多发性杜氏菌菌剂量方案的疗效和安全性
2. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial [J] . Thaci Diamant, Simpson Eric L., Beck Lisa A., The Lancet . 2016,第10013期

机译：局部治疗不足以控制中度至重度特应性皮炎的成人dupilumab的疗效和安全性：一项随机，安慰剂对照，剂量范围为2b的试验
3. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial [J] . Thaci Diamant, Simpson Eric L., Beck Lisa A., The Lancet . 2016,第10013期

机译：局部治疗不足以控制中度至重度特应性皮炎的成人dupilumab的疗效和安全性：一项随机，安慰剂对照，剂量范围为2b的试验
4. A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update [C] . Thierry Olivry, Petra Bizikova World Congress of Veterinary Dermatology . 2013

机译：对狗的预防或治疗特应性皮炎的随机对照试验进行系统综述：2008-2011更新
5. Topical Probiotics in the Treatment of Atopic Dermatitis: A Randomized Controlled Trial [D] . Chen, Jessica. 2018

机译：局部益生菌治疗特应性皮炎：随机对照试验
6. Efficacy and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis: meta-analysis of randomized clinical trials [O] . Natalia £abędź, Rafał Pawliczak 2019

机译：局部钙调神经磷酸酶抑制剂治疗特应性皮炎的有效性和安全性：随机临床试验的荟萃分析
7. Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis [O] . Margitta Worm, Eric L. Simpson, Diamant Thaçi, 2020

机译：特应性皮炎患者初始成功治疗后多种杜比拉剂剂量方案的疗效和安全性

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial

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