Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism

DAntoni Michelle L.; Paul Robert H.; Mitchell Brooks I.; Kohorn Lindsay; Fischer Laurent; Lefebvre Eric; Seyedkazemi Star; Nakamoto Beau K.; Walker Maegen; Kallianpur Kalpana J.; Ogata-Arakaki Debra; Ndhlovu Lishomwa C.; Shikuma Cecilia

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Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism

机译：在双CCR2和CCR5拮抗作用后，改善了在病毒抑制慢性HIV中的认知性能和单核细胞活化降低

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Objective: To evaluate changes in neuropsychological (NP) performance and in plasma and cell surface markers of peripheral monocyte activation/migration after treatment with cenicriviroc (CVC), a dual C-C chemokine receptor type 2 (CCR2) and type 5 (CCR5) antagonist, in treatment-experienced, HIV-infected individuals.

机译：目的：评价用Cenicriroc（CVC）处理后神经心理学（NP）性能和血浆和细胞表面标志物，双CC趋化因子受体2（CCR2）和型5（CCR5）拮抗剂，在治疗经验丰富的艾滋病毒感染的个体。

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来源
《JAIDS: Journal of acquired immune deficiency syndromes 》 |2018年第1期| 共9页
作者
DAntoni Michelle L.; Paul Robert H.; Mitchell Brooks I.; Kohorn Lindsay; Fischer Laurent; Lefebvre Eric; Seyedkazemi Star; Nakamoto Beau K.; Walker Maegen; Kallianpur Kalpana J.; Ogata-Arakaki Debra; Ndhlovu Lishomwa C.; Shikuma Cecilia;
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作者单位

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Missouri St Louis MO 63121 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Allergan San Francisco CA USA;

Allergan San Francisco CA USA;

Allergan San Francisco CA USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Hawaii Manoa Dept Psychol Honolulu HI 96822 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

Univ Hawaii Hawaii Ctr AIDS Honolulu HI 96813 USA;

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原文格式 PDF
正文语种 eng
中图分类传染病 ;
关键词
(3-6): C-C chemokine receptor type 2 and 5; monocytes; HIV; antiretroviral therapy; cognitive impairment; clinical trials;

机译：（3-6）：C-C趋化因子受体2和5型;单核细胞;艾滋病毒;抗逆转录病毒治疗;认知障碍;临床试验;

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专利

1. Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism [J] . DAntoni Michelle L., Paul Robert H., Mitchell Brooks I., JAIDS: Journal of acquired immune deficiency syndromes . 2018 ,第1期

机译：在双CCR2和CCR5拮抗作用后，改善了在病毒抑制慢性HIV中的认知性能和单核细胞活化降低
2. Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups. [J] . Wang FS, Hong WG, Cao Y, JAIDS: Journal of acquired immune deficiency syndromes . 2003 ,第2期

机译：在中国本土健康个体以及HIV-1风险人群中HIV-1感染者和HIV-1感染者中CCR5 delta32，CCR5 m303，CCR2b 64I和SDF1 3'A等位基因频率的人群调查。
3. The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline [J] . Kramer Victor G., Hassounah Said, Colby-Germinario Susan P., The Journal of Antimicrobial Chemotherapy . 2015 ,第3期

机译：CCR5和CCR2双重抑制剂cenicriviroc不会将HIV重新分布到细胞外空间：对血浆病毒载量和细胞内DNA下降的影响
4. Dual Metal (DM) Insulated Shallow Extension (ISE) Gate All Around (GAA) MOSFET to Reduce Gate Induced Drain Leakages (GIDL) for Improved Analog Performance [C] . Sonam Rewari, Vandana Nath, Subhasis Haldar, International Conference on Devices for Integrated Circuit . 2017

机译：双金属（DM）绝缘浅延伸（ISE）门全部（GAA）MOSFET，以减少栅极诱导的漏极泄漏（GID1），以改善模拟性能
5. Multidimensional perceptual -cognitive skills training reduces spatio-temporal errors and improves dynamic performance among seniors. [D] . Caserta, Ryan J. 2007

机译：多维的感知-认知技能培训减少了时空错误，并改善了老年人的动态表现。
6. Improved Cognitive Performance and Reduced Monocyte Activation inVirally Suppressed Chronic HIV Following Dual CCR2 and CCR5Antagonism [O] . Michelle L. D’Antoni, Robert H. Paul, Brooks I. Mitchell, -1

机译：改善认知能力并减少单核细胞活化双重抑制CCR2和CCR5后病毒抑制慢性HIV对抗
7. Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism [O] . Michelle L. DAntoni, Robert H. Paul, Brooks I. Mitchell, 2018

机译：在双CCR2和CCR5拮抗作用后，改善了在病毒抑制慢性艾滋病毒中的认知性能和减少单核细胞活化
8. CCL3L1-CCR5 Genotype Improves the Assessment of AIDS Risk in HIV-1- Infected Individuals [R] . 2008

机译：CCL3L1-CCR5基因型改善HIV-1感染者的艾滋病风险评估

Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism

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