Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

摘要

Highlights ? Appetitive hormones were examined in cocaine users after intravenous (IV) cocaine administration. ? Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) serum concentrations decreased 60min after IV cocaine administration. ? Such changes were linked to cardiorespiratory and subjective responses to IV cocaine. Abstract Background Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine administration on the blood concentrations of these hormones in cocaine users. Methods We evaluated serum concentrations of six appetitive hormones: ghrelin (total and acyl-ghrelin), amylin, glucagon-like peptide-1 (GLP-1), insulin, leptin and peptide YY (PYY), as well as acute cardiorespiratory and subjective responses of 8 experienced cocaine users who received 25mg intravenous (IV) cocaine. Results Serum concentrations of GLP-1 ( p =0.014) and PYY ( p =0.036) were significantly decreased one hour following IV cocaine administration; there was a trend towards a decrease for insulin ( p =0.055) and amylin ( p =0.063) concentrations, while no significant IV cocaine effect was observed for ghrelin (total or acyl-ghrelin) or leptin concentrations ( p ’ s?> 0.5). We also observed associations between hormone concentrations acutely affected by IV cocaine (GLP-1, PYY, insulin, amylin) and some cocaine-related cardiorespiratory and subjective responses ( e.g ., increased heart and respiratory rates; feeling high and anxious). Discussion These findings show a significant effect of acute IV cocaine administration on some appetitive hormones and suggest potential associations between these hormones and cocaine-related cardiorespiratory and subjective responses. Additional research is needed to further investigate the potential mechanisms underlining these associations.