首页> 外文期刊>Diagnostic microbiology and infectious disease >Anti-Mycobacterium avium complex activity of clarithromycin, rifampin, rifabutin, and ethambutol in combination with adenosine 5 '-triphosphate
【24h】

Anti-Mycobacterium avium complex activity of clarithromycin, rifampin, rifabutin, and ethambutol in combination with adenosine 5 '-triphosphate

机译:酸霉素,利福平,利福比蛋白和乙胺醇的抗分子丙啶络合物活性与腺苷5' - 三磷酸酯组合

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

We previously reported that adenosine 5 '-triphosphate (ATP) inhibited the growth of various bacteria, including mycobacteria, Staphylococcus, and Pseudomonas, without damaging bacterial surface structures. Notably, ATP's antibacterial activity was found to be attributable to its iron-chelating ability. ATP exhibited combined effects with some antimicrobials against Mycobacterium intracellulare and methicillin-resistant S. aureus, suggesting its usefulness as an adjunctive drug in the chemotherapy against certain intractable infections. In this study, we examined detailed profiles of the anti-Mycobacterium avium complex (MAC) activity of some antimicrobial agents, including clarithromycin (CIA), rifampin (RIF), rifabutin (RBT), and ethambutol (EMB), in combination with ATP. It was found that the anti-MAC activity of CLA + RIF, CIA + RBT, and CIA + EMB was markedly potentiated in a strain-dependent manner. In this case, the onset of the regrowth of antimicrobial agent-treated mycobacteria during cultivation was significantly delayed in the presence of ATP, indicating the usefulness of ATP as an adjunctive drug in chemotherapy against MAC infections. (C) 2017 Elsevier Inc. All rights reserved.
机译:我们之前报道,腺苷5' - 三磷酸(ATP)抑制了各种细菌的生长,包括分枝杆菌,葡萄球菌和假单胞菌,而不会破坏细菌表面结构。值得注意的是,发现ATP的抗菌活性可归因于其铁螯合能力。 ATP与一些抗菌药物和甲氧西林抗性S.金黄色葡萄球菌的一些抗微生物表现出综合影响,这表明其在化疗中的辅助药物免受某些顽固性感染的有用性。在这项研究中,我们研究了一些抗微生物剂(Cia),利福平(RIF),利福纳蛋白(RBT)和乙胺丁醇(胚号),与ATP组合。发现CLA + RIF,CIA + RBT和CIA + MEB的抗MAC活性以应变依赖性方式显着提升。在这种情况下,在培养过程中抗菌药物治疗的分枝杆菌的再生开始在ATP存在下显着延迟,表明ATP作为化疗中的辅助药物免受MAC感染的有用性。 (c)2017年Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号