首页> 外文期刊>Hormone and Metabolic Research >Associations of TNFRSF1A Polymorphisms with Autoimmune Thyroid Diseases: A Case-Control Study
【24h】

Associations of TNFRSF1A Polymorphisms with Autoimmune Thyroid Diseases: A Case-Control Study

机译:TNFRSF1A多态性与自身免疫性甲状腺疾病的关联:案例对照研究

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

Previous studies have shown associations of polymorphisms in the tumor necrosis factor (TNF) receptor super family member 1A ( TNFRSF1A ) gene with several groups of inflammatory and autoimmune related diseases, but associations of TNFRSF1A polymorphisms with autoimmune thyroid diseases (AITD), mainly including two sub-types of Hashimoto's thyroiditis (HT) and Graves' disease (GD), in the Chinese Han population is unclear. A case-control study of 1812 subjects (965 AITD patients and 847 unrelated healthy controls) was conducted to assess AITD associations with five single nucleotide polymorphisms (SNPs), including rs4149576, rs4149577, rs4149570, rs1800693, and rs767455 in the TNFRSF1A gene locus. Genotyping was performed and evaluated using the platform of ligase detection reaction. No significant difference was observed in the allele and genotype frequencies between HT or GD patients and controls in any of the five SNPs in the TNFRSF1A gene (all p values 0.05). However, a moderate association of rs4149570 with HT was found after adjusting for age and gender [odds ratio (OR)=1.40, p=0.03]. No obvious difference was found in the haplotype distribution of any of the five SNPs in the TNFRSF1A gene between the AITD patients and controls. These data suggest that these five SNPs in the TNFRSF1A gene are not associated with AITD in the Chinese Han population, but rs4149570 shows a weak association with HT after adjusting for gender and age.
机译:以前的研究表明,具有几组炎症和自身免疫相关疾病的肿瘤坏死因子(TNF)受体超级家族成员1A(TNFRSF1A)基因的多态性关联,但TNFRSF1A多态性与自身免疫性甲状腺疾病(AITD)的关联,主要包括两个在中国汉族人群中,哈希莫托氏甲状腺炎(HT)和Graves疾病(GD)尚不清楚。对1812项受试者(965例AITD患者和847名无关的健康对照组)进行病例对照研究,以评估具有五种单一核苷酸多态性(SNP)的AITD关联,包括TNFRSF1A基因基因座中的RS4149576,RS4149577,RS4149570,RS4149570,RS767455。使用连接酶检测反应平台进行基因分型和评估。在TNFRSF1A基因中的任何五个SNP中的HT或GD患者之间的等位基因和基因型频率中没有观察到显着差异(所有P值& 0.05)。然而,在调整年龄和性别(OR)= 1.40,P = 0.03]后发现,在调整年龄和性别(或)= 1.40]后,发现了与HT的中度关联。在AITD患者和对照组之间的TNFRSF1A基因中的任何五个SNP中的任何一种的单倍型分布中没有发现明显差异。这些数据表明,TNFRSF1A基因中的这五个SNP与中国汉族人口中的AITD无关,但调整性别和年龄后,RS4149570显示了与HT薄弱。

著录项

  • 来源
    《Hormone and Metabolic Research》 |2018年第2期|共8页
  • 作者单位

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Weinan Cent Hosp Dept Nephrol &

    Endocrinol Weinan Peoples R China;

    Shanghai Univ Med &

    Hlth Sci Affiliated Zhoupu Hosp Dept Endocrinol Shanghai Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

    Fudan Univ Jinshan Hosp Dept Endocrinol 1508 Longhang Rd Shanghai 201508 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    TNFRSF1A; autoimmune thyroid diseases; single nucleotide polymorphism;

    机译:TNFRSF1A;自身免疫性甲状腺疾病;单核苷酸多态性;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号