Clinical and neurobiological effects of aerobic exercise in dental phobia: A randomized controlled trial

Lindenberger Brigitt L.; Plag Jens; Schumacher Sarah; Gaudlitz Katharina; Bischoff Sophie; Bobbert Thomas; Dimeo Fernando; Petzold Moritz B.; Kirschbaum Clemens; Dudás Zsuzsa; Str?hle Andreas

摘要

Background >Physical activity has shown to be effective in anxiety disorders. For specific phobia, no studies are available that systematically examined the effects of an aerobic exercise intervention on phobic fear within a randomized‐controlled design. Therefore, we investigated the acute effect of a standardized aerobic training on clinical symptoms of dental phobia as well as on stress‐related neurobiological markers. </section> <section xml:id="da22659-sec-0020"> <title type="main">Methods > Within a crossover design, 30 patients with dental phobia (mean age: 34.1 years; mean score of the Dental Anxiety Scale: 18.8) underwent two minor dental interventions separated by 7 days. Dental treatment was performed after 30 min of physical activity at either 20% VO <sub>2 max</sub> (control) or 70% VO <sub>2 max</sub> (intervention), respectively. To control for habituation, patients were randomly assigned to one of the two conditions prior to the first intervention. Moreover, saliva samples were collected at five times in order to determine changes in salivary cortisol (sC) and alpha‐amylase (sAA) due to treatment. </section> <section xml:id="da22659-sec-0030"> <title type="main">Results > In comparison to baseline, aerobic exercise within 70% VO <sub>2 max</sub> significantly reduced clinical anxiety and sC concentrations before, during, and after the dental treatment. In contrast, the control condition led to decreased sAA levels at different time points of measurement. Habituation occurred at the second study day, independent of the order. </section> <section xml:id="da22659-sec-0040"> <title type="main">Conclusio </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <第XML：ID =“da22659-ec-0010”> <标题类型=“main”>背景</ title> >物理活动已显示焦虑症有效。对于特定的恐惧症，没有任何研究可以系统地检查有氧运动干预对随机控制设计中的恐惧恐惧的影响。因此，我们调查了标准化的有氧训练对牙科恐惧症的临床症状以及应激相关神经生物学标志物的急性效应。</ p> </ section> <section XML：ID =“DA22659-SEC-0020”> <标题类型=“main”>方法</ title> >在交叉设计中，30例牙恐惧症患者（平均年龄：34.1岁;平均焦虑症的得分：18.8）接受了两次轻微的牙科干预措施7天。在20％VO <sub> 2最大>（对照）或70％VO <sub> 2max </ sub>（干预）的30％的物理活性后进行牙科治疗。为了控制习惯，在第一次干预之前将患者随机分配给两个条件之一。此外，唾液样品在五次中收集，以确定由于治疗的唾液皮质醇（SC）和α-淀粉酶（SAA）的变化。 </ p> </ section> <section xml：id =“da22659-sec-0030”> <标题类型=“main”>结果</ title> >与基线相比，有氧运动70％VO < Sub> 2 Max </ sub>在牙科治疗之前，期间和之后显着降低了临床焦虑和SC浓度。相反，控制条件导致不同时间测量点的SAA水平降低。习惯发生在第二学习日，独立于订单。 </ p> </ section> <section XML：ID =“DA22659-SEC-0040”> <标题类型=“main”>结论 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety 》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b> <span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lindenberger Brigitt L.&option=202" target="_blank" rel="nofollow">Lindenberger Brigitt L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Plag Jens&option=202" target="_blank" rel="nofollow">Plag Jens;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schumacher Sarah&option=202" target="_blank" rel="nofollow">Schumacher Sarah;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gaudlitz Katharina&option=202" target="_blank" rel="nofollow">Gaudlitz Katharina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bischoff Sophie&option=202" target="_blank" rel="nofollow">Bischoff Sophie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bobbert Thomas&option=202" target="_blank" rel="nofollow">Bobbert Thomas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dimeo Fernando&option=202" target="_blank" rel="nofollow">Dimeo Fernando;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Petzold Moritz B.&option=202" target="_blank" rel="nofollow">Petzold Moritz B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kirschbaum Clemens&option=202" target="_blank" rel="nofollow">Kirschbaum Clemens;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dudás Zsuzsa&option=202" target="_blank" rel="nofollow">Dudás Zsuzsa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Str?hle Andreas&option=202" target="_blank" rel="nofollow">Str?hle Andreas;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of EndocrinologyCampus Charité MitteBerlin Germany;</p> <p>Section of Sports MedicineCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Biological PsychologyTechnische Universit?t DresdenGermany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> <p>Department of Psychiatry and PsychotherapyCharité—Universit?tsmedizin BerlinBerlin Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alpha‐amylase&option=203" rel="nofollow">alpha‐amylase;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety/anxiety disorders&option=203" rel="nofollow">anxiety/anxiety disorders;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=clinical trials&option=203" rel="nofollow">clinical trials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cortisol&option=203" rel="nofollow">cortisol;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=exercise&option=203" rel="nofollow">exercise;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phobia/phobic disorders&option=203" rel="nofollow">phobia/phobic disorders;</a> </p> <div class="translation"> 机译：α-淀粉酶;焦虑/焦虑症;临床试验;皮质醇;运动;恐惧症/恐惧症; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195599.html">Clinical and neurobiological effects of aerobic exercise in dental phobia: A randomized controlled trial</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lindenberger Brigitt L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lindenberger Brigitt L.,</a> <a 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href="/academic-journal-cn_china-medicine-pharmacy_thesis/0201254364440.html">糖皮质激素在体外循环下心脏手术中肺保护作用临床随机对照试验的Meta分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=单文斌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 单文斌</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘凯&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘凯</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胡继宏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,胡继宏</a> <span> <a href="/journal-cn-6709/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国医药科学 </a> </span> <span> . 2016</span><span> ,第009期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-medicine-pharmacy_thesis/0201254496906.html">视网膜Müller细胞的胶质化激活在实验性青光眼大鼠模型中的作用--复旦大学神经生物学研究所杨雄里院士访谈录</a> <b>[J]</b> <span> <a 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</div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130499769658.html">A computer system that produces a randomized and clinical trial supply management (RTSM) system for clinical trials</a> <b>[P]</b> . <span> 外国专利：  JP6857661B2 </span> <span> . 2021-04-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一种用于临床试验的随机和临床试验供应管理（RTSM）系统的计算机系统 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130404905721.html">Computer system for generating randomized and clinical trial supply management (RTSM) systems for clinical trials</a> <b>[P]</b> . <span> 外国专利：  JP2018538641A </span> <span> . 2018-12-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> 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