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Treatment of premenstrual dysphoria with continuous versus intermittent dosing of oral contraceptives: Results of a three‐arm randomized controlled trial

机译：持续的患有持续的口腔避孕药的持续性患者的经常患者的治疗：三臂随机对照试验的结果

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Background >Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some randomized controlled trials (RCTs) indicate that oral contraceptives administered with a shortened or eliminated hormone‐free interval are superior to placebo. However, results of such trials are mixed, and no existing studies have directly compared continuous and intermittent dosing schedules of the same oral contraceptive. The present study compared placebo, intermittent dosing of oral contraceptives, and continuous dosing of contraceptives for the treatment of PMD. </section> <section xml:id="da22673-sec-0020"> <title type="main">Methods > Fifty‐five women with prospectively confirmed PMD completed a three‐arm, RCT in which they were randomized to 3 months of placebo ( n = 22), intermittent drospirenone/ethinyl estradiol dosed on a 21–7 schedule ( n = 17), or continuous drospirenone/estradiol ( n = 16) following a baseline assessment month. </section> <section xml:id="da22673-sec-0030"> <title type="main">Results >All three groups demonstrated similar, robust reductions in premenstrual symptoms over time. A marked placebo response was observed. </section> <section xml:id="da22673-sec-0040"> <title type="main">Conclusions >The study fails to replicate a uniquely beneficial effect of continuous COC on PMD. Additional work is needed to understand the psychosocial context bolstering the placebo response in women with PMD. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <第XML：ID =“da22673-ec-0010”> <标题类型=“main”>背景</ title> >虽然传统上提醒口服避孕药（COCs）（活性丸的21天，7天的非活性丸）尚未被证明为安慰剂治疗过早性困难（PMD），一些随机对照试验（RCT）表明口服避孕药缩短给予缩短或消除的激素间隔优于安慰剂。然而，这种试验的结果是混合的，并且没有现有的研究直接比较了相同口腔避孕药的连续和间歇的给药时间表。本研究比较安慰剂，间歇剂量的口腔避孕药，以及用于治疗PMD的避孕药的连续给药。</ p> </截面> <截面XML：ID =“DA22673-SEC-0020”> <标题类型=“主要“>方法</ title> >预期确认PMD的五十五名妇女完成了一个三臂，其随机调整为3个月的安慰剂（ n </ i> = 22），间歇性在基线评估月后，在21-7时刻表（ N </ I> = 17）中，或连续的替代血酮/雌二醇（ n = 16），或连续的替代司酮/雌二醇（ n </ i> = 16）。 </ p> </ section> <section XML：ID =“DA22673-SEC-0030”> <标题类型=“main”>结果</ title> >所有三组在明确症状中展示相似，鲁棒减少时间。观察到标记的安慰剂响应。</ p> </ section> <section xml：id =“da22673-sec-0040”> <标题类型=“main”>结论</ title> >该研究无法复制连续COC对PMD的独特效益。需要额外的工作来了解借助PMD妇女安慰剂的心理社会上下文。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2017年第10期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eisenlohr‐Moul Tory A.&option=202" target="_blank" rel="nofollow">Eisenlohr‐Moul Tory A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Girdler Susan S.&option=202" target="_blank" rel="nofollow">Girdler Susan S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Johnson Jacqueline L.&option=202" target="_blank" rel="nofollow">Johnson Jacqueline L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmidt Peter J.&option=202" target="_blank" rel="nofollow">Schmidt Peter J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rubinow David R.&option=202" target="_blank" rel="nofollow">Rubinow David R.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PsychiatryUniversity of North CarolinaChapel Hill NC USA;</p> <p>Department of PsychiatryUniversity of North CarolinaChapel Hill NC USA;</p> <p>Department of PsychiatryUniversity of North CarolinaChapel Hill NC USA;</p> <p>Section on Behavioral EndocrinologyNIMH IRPBethesda MD USA;</p> <p>Department of PsychiatryUniversity of North CarolinaChapel Hill NC USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oral contraceptives&option=203" rel="nofollow">oral contraceptives;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=premenstrual syndrome&option=203" rel="nofollow">premenstrual syndrome;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=randomized controlled trial&option=203" rel="nofollow">randomized controlled trial;</a> </p> <div class="translation"> 机译：口服避孕药;经常综合征;随机对照试验; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195513.html">Treatment of premenstrual dysphoria with continuous versus intermittent dosing of oral contraceptives: Results of a three‐arm randomized controlled trial</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eisenlohr‐Moul Tory A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Eisenlohr‐Moul Tory A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Girdler Susan S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Girdler Susan S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Johnson Jacqueline L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Johnson Jacqueline L.,</a> <a href="/journal-foreign-32884/" target="_blank" rel="nofollow" class="tuijian_authcolor">Depression and anxiety .</a> <span>2017</span><span>,第10期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：持续的患有持续的口腔避孕药的持续性患者的经常患者的治疗：三臂随机对照试验的结果</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/070405463642.html">Calcium versus oral contraceptive pills containing drospirenone for the treatment of mild to moderate premenstrual syndrome: a double blind randomized placebo controlled trial</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shehata Nesreen A. 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