The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women

Gillis Jennifer Cai; Chang Shun‐Chiao; Wang Wei; Simon Naomi M.; Normand Sharon‐Lise; Rosner Bernard A.; Blacker Deborah; DeVivo Immaculata; Okereke Olivia I.

摘要

Abstract <section xml:id="da22892-sec-0010" numbered="no"> <title type="main">Background >Telomeres cap and protect DNA but shorten with each somatic cell division. Aging and environmental and lifestyle factors contribute to the speed of telomere attrition. Current evidence suggests a link between relative telomere length (RTL) and depression but the directionality of the relationship remains unclear. We prospectively examined associations between RTL and subsequent depressive symptom trajectories. </section> <section xml:id="da22892-sec-0020" numbered="no"> <title type="main">Methods >Among 8,801 women of the Nurses’ Health Study, depressive symptoms were measured every 4 years from 1992 to 2012; group‐based trajectories of symptoms were identified using latent class growth‐curve analysis. Multinomial logistic models were used to relate midlife RTLs to the probabilities of assignment to subsequent depressive symptom trajectory groups. </section> <section xml:id="da22892-sec-0030" numbered="no"> <title type="main">Results > We identified four depressive symptom trajectory groups: minimal depressive symptoms (62%), worsening depressive symptoms (14%), improving depressive symptoms (19%), and persistent‐severe depressive symptoms (5%). Longer midlife RTLs were related to significantly lower odds of being in the worsening symptoms trajectory versus minimal trajectory but not to other trajectories. In comparison with being in the minimal symptoms group, the multivariable‐adjusted odds ratio of being in the worsening depressive symptoms group was 0.78 (95% confidence interval, 0.62–0.97; p ?=?0.02), for every standard deviation increase in baseline RTL. </section> <section xml:id="da22892-sec-0040" numb </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <标题类型=“main”>抽象</ title> <section XML：ID =“da22892-ec-0010”编号=“否”> <标题类型=“main”>背景</ title> >端粒帽并保护DNA，但用每个体细胞分裂缩短。老化和环境和生活方式因素有助于端粒磨损的速度。目前的证据表明相对端粒长度（RTL）和抑郁之间的联系，但关系的方向性仍然不明确。我们潜入RTL和随后的抑郁症状轨迹之间的关联。</ p> </段> <部分XML：ID =“da22892-ec-0020”编号=“否”> <标题类型=“main”>方法</标题> >在护士卫生研究的8,801名女性中，从1992年到2012年每4年测量抑郁症状;使用潜在阶级的生长曲线分析确定基于组的症状轨迹。多项式物流模型用于将中期RTL与分配的概率联系起来给随后的抑郁症状轨迹组。</ p> </ section> <章节XML：ID =“da22892-ec-0030”编号=“否”> <标题类型=“main”>结果</标题> >我们确定了四种抑郁症状轨迹组：最小抑郁症状（62％），恶化抑郁症状（14％），改善抑郁症状（19％），持续严重抑郁症状（5％）。较长的中期RTL与在恶化的症状轨迹与最小轨迹相比下显着较低，但不是其他轨迹。与在最小症状组中，在恶化抑郁症状组中的多变量调整的差距为0.78（95％置信区间，0.62-0.97; P </ i>？=？0.02），对于基线RTL的每个标准偏差增加。 </ p> </ section> <section XML：ID =“DA22892-SEC-0040”NUMB </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety 》</a> <b style="margin: 0 2px;">|</b><span>2019年第6期</span><b style="margin: 0 2px;">|</b> <span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gillis Jennifer Cai&option=202" target="_blank" rel="nofollow">Gillis Jennifer Cai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Shun‐Chiao&option=202" target="_blank" rel="nofollow">Chang Shun‐Chiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Wei&option=202" target="_blank" rel="nofollow">Wang Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Simon Naomi M.&option=202" target="_blank" rel="nofollow">Simon Naomi M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Normand Sharon‐Lise&option=202" target="_blank" rel="nofollow">Normand Sharon‐Lise;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rosner Bernard A.&option=202" target="_blank" rel="nofollow">Rosner Bernard A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Blacker Deborah&option=202" target="_blank" rel="nofollow">Blacker Deborah;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DeVivo Immaculata&option=202" target="_blank" rel="nofollow">DeVivo Immaculata;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Okereke Olivia I.&option=202" target="_blank" rel="nofollow">Okereke Olivia I.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> <p>Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston Massachusetts;</p> <p>Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston Massachusetts;</p> <p>Department of PsychiatryMassachusetts General Hospital and Harvard Medical SchoolBoston Massachusetts;</p> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> <p>Department of EpidemiologyHarvard T.H. Chan School of Public HealthBoston Massachusetts;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=depression&option=203" rel="nofollow">depression;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=depressive symptoms&option=203" rel="nofollow">depressive symptoms;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=late‐life&option=203" rel="nofollow">late‐life;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=telomeres&option=203" rel="nofollow">telomeres;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=trajectories&option=203" rel="nofollow">trajectories;</a> </p> <div class="translation"> 机译：抑郁症;抑郁症状;晚期;端粒;轨迹; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195325.html">The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women</a> <b>[J]</b> . <span> <a 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