TGF-beta(1) and contact mediated suppression by CD4(+)CD25(+)CD127(-) T regulatory cells of patients with self-limiting hepatitis E

摘要

Background and aim: Literature on the role of Regulatory T cells (Tregs) in acute viral infections is limited. Having established that the Tregs in self-limiting hepatitis E infection are elevated and functional, this study has focused on characterizing the specificity, phenotypes and identifying the molecules or factors responsible for enhancement of Treg cells and abrogation of Treg-mediated suppression in hepatitis E.