<i >Helicobacter pyloriHelicobacter pylori        infection‐induced H3Ser10 phosphorylation in stepwise gastric carcinogenesis and its clinical implications

Yang Tao‐Tao; Cao Na; Zhang Hai‐Hui; Wei Jian‐Bo; Song Xiao‐Xia; Yi Dong‐Min; Chao Shuai‐Heng; Zhang Li‐Da; Kong Ling‐Fei; Han Shuang‐Yin; Yang Yu‐Xiu; Ding Song‐Ze

摘要

Abstract <section numbered="no" xml:id="hel12486-sec-0001"> <title type="main">Background > Our previous works have demonstrated that Helicobacter pylori ( Hp ) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori ‐induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. </section> <section numbered="no" xml:id="hel12486-sec-0002"> <title type="main">Materials and Methods > Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index. They were categorized into nonatrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, low‐grade intraepithelial neoplasia, high‐grade intraepithelial neoplasia, and intestinal‐type gastric cancer groups. Helicobacter pylori infection was determined by either 13 C‐urea breath test or immunohistochemistry staining. </section> <section numbered="no" xml:id="hel12486-sec-0003"> <title type="main">Results > In Helicobacter pylori ‐negative patients, labeling index of histone H3 serine 10 phosphorylation was gradually increased in nonatrophic gastritis, chronic atrophic gastritis, intestinal metaplasia groups, peaked at low‐grade intraepithelial ne </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12486-Abs-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> <sectouned =“no”xml：id = “hel12486-sec-0001”> <标题类型=“main”>背景</ title> >我们之前的作品已经证明幽门螺杆菌（ hp </ i>）感染可以改变胃上皮细胞中的组蛋白H3丝氨酸10磷酸化状态。然而，无论是幽门螺杆菌 - 诱导的组蛋白H3丝氨酸10磷酸化参与胃癌是否未知。我们研究了组蛋白H3丝氨酸10在胃病各个阶段的表达，探讨了其临床意义。 </ p> </ section> <部分编号=“否”XML：ID =“HEL12486-SEC-0002”> <标题类型=“MAIN”>材料和方法</标题> <P>胃活检样本129收集患者并用组蛋白H3丝氨酸10磷酸化，KI67和通过免疫组化染色染色，表示为标记指数。它们被分为非营养性胃炎，慢性萎缩性胃炎，肠道成型，低级术前皮瘤，高级宫内节育瘤和肠型胃癌组。幽门螺杆菌幽门螺杆菌感染通过 13-sup> c-尿素呼气试验或免疫组化染色来测定。 </ p> </段> <部分编号=“否”XML：ID =“Hel12486-SEC-0003”> <标题类型=“main”>结果</标题> >在幽门螺杆菌中< / i> - 儿童患者，组蛋白H3丝氨酸的标记指数在非竞技胃炎中逐渐增加，慢性萎缩性胃炎，肠道胰腺炎，在低级上皮内皮上达到峰值 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Tao‐Tao&option=202" target="_blank" rel="nofollow">Yang Tao‐Tao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cao Na&option=202" target="_blank" rel="nofollow">Cao Na;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Hai‐Hui&option=202" target="_blank" rel="nofollow">Zhang Hai‐Hui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wei Jian‐Bo&option=202" target="_blank" rel="nofollow">Wei Jian‐Bo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Song Xiao‐Xia&option=202" target="_blank" rel="nofollow">Song Xiao‐Xia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yi Dong‐Min&option=202" target="_blank" rel="nofollow">Yi Dong‐Min;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chao Shuai‐Heng&option=202" target="_blank" rel="nofollow">Chao Shuai‐Heng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Li‐Da&option=202" target="_blank" rel="nofollow">Zhang Li‐Da;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kong Ling‐Fei&option=202" target="_blank" rel="nofollow">Kong Ling‐Fei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Han Shuang‐Yin&option=202" target="_blank" rel="nofollow">Han Shuang‐Yin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Yu‐Xiu&option=202" target="_blank" rel="nofollow">Yang Yu‐Xiu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Song‐Ze&option=202" target="_blank" rel="nofollow">Ding Song‐Ze;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Henan Police CollegeZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyXinxiang Medical UniversityXinxiang China;</p> <p>Department of PathologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of PathologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> <p>Department of Gastroenterology and HepatologyPeople's Hospital of Zhengzhou UniversityZhengzhou China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epigenetic&option=203" rel="nofollow">epigenetic;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gastric cancer&option=203" rel="nofollow">gastric cancer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=H3 serine 10 phosphorylation&option=203" rel="nofollow">H3 serine 10 phosphorylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=histone modification&option=203" rel="nofollow">histone modification;</a> </p> <div class="translation"> 机译：表观遗传;胃癌;H3丝氨酸10磷酸化;幽门螺杆菌;组蛋白修饰; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025099107.html"><i >Helicobacter pyloriHelicobacter pylori infection‐induced H3Ser10 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<a href="/journal-cn-5958/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 临床内科杂志 </a> </span> <span> . 2020</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-digestion-intervention_thesis/0201273519298.html">胃癌组织中幽门螺杆菌感染和p-p65、EMT相关蛋白的表达及临床意义</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谭林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 谭林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王骞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王骞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=屈伟明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,屈伟明</a> <span> <a href="/journal-cn-6040/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 现代消化及介入诊疗 </a> </span> <span> . 2019</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_carcinogenesis-teratogenesis-mutagenesis_thesis/0201236261474.html">Gadd45α在不同幽门螺杆菌感染状态胃癌中的差异表达及临床意义</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯水土&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 冯水土</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈毅德&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈毅德</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈玉强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈玉强</a> <span> <a href="/journal-cn-6199/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 癌变·畸变·突变 </a> </span> <span> . 2016</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modern-journal-integrated-traditional-chinese-western-medicine_thesis/0201218604270.html">幽门螺杆菌感染性胃癌组织中Legumain、 MMP-9的表达及其临床意义</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=汤新跃&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 汤新跃</a> <span> <a href="/journal-cn-5687/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 现代中西医结合杂志 </a> </span> <span> . 2015</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-1544_thesis/02022199401.html">胃癌Ⅰ类相关因子幽门螺杆菌感染小鼠体内TLR4及Treg在幽门螺杆菌感染及胃粘膜炎症程度中的相关性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=龚燕锋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 龚燕锋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谢勇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘焕兵&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘焕兵</a> <span> <a href="/conference-cn-1544/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2015中国老年医学和老年健康产业大会 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311551477.html">肝素酶在幽门螺杆菌感染致胃癌发病机制中的作用及其临床意义</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘丽平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘丽平</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204358151.html">GSDMD抑制剂在制备治疗幽门螺杆菌感染的药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN111529707B </span> <span> . 2021.04.23</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120113386445.html">梅花草提取物在制备治疗幽门螺杆菌感染疾病药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN113413402A </span> <span> . 2021-09-21</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130450891686.html">Vaccine composition, use of a helicobacter pylori polypeptide flge or a modified form thereof, use of the same, vaccine composition to induce a protective immune response to helicobacter pylori infection, in vitro diagnostic process of helicobacter pylori infection, kit method for detecting helicobacter pylori infection in a mammal including man, and process for eliciting a protective immune response against helicobacter pylori infection in a mammal</a> <b>[P]</b> . <span> 外国专利：  BR9810026A </span> <span> . 2000-09-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疫苗组合物，幽门螺杆菌多肽壁或其修饰形式的用途，其用途，疫苗组合物诱导对幽门螺杆菌感染的保护性免疫应答，幽门螺杆菌感染的体外诊断方法，用于检测幽门螺杆菌感染的试剂盒方法包括人在内的哺乳动物中的表达，以及引起针对幽门螺杆菌感染的保护性免疫应答的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130449100227.html">Compound, process for the preparation of it, pharmaceutical formulation, use of the compound, processes to inhibit gastric acid secretion, for the treatment of inflammatory gastrointestinal diseases, and for the treatment or prophylaxis of conditions involving helicobacter pylori infection of the mucosa human gastric, and, pharmaceutical formulations for use in inhibiting gastric acid secretion, for use in the treatment of inflammatory gastrointestinal diseases, and for use in the treatment or prophylaxis of conditions involving helicobacter pylori infection of the human gastric mucosa</a> <b>[P]</b> . <span> 外国专利：  BR9913103A </span> <span> . 2001-05-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：该化合物，其制备方法，药物制剂，该化合物的使用，抑制胃酸分泌的方法，用于治疗炎性胃肠疾病以及用于治疗或预防人胃黏膜幽门螺杆菌感染的疾病的方法，以及用于抑制胃酸分泌，用于治疗炎性胃肠疾病以及用于治疗或预防涉及人胃粘膜的幽门螺杆菌感染的疾病的药物制剂 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130425480225.html">composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion</a> <b>[P]</b> . <span> 外国专利：  BRPI0617987A2 </span> <span> . 2011-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> 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