High primary antibiotic resistance of        <i >Helicobacter PyloriHelicobacter Pylori        strains isolated from dyspeptic patients: A prevalence cross‐sectional study in Spain

Macías‐García Fernando; Llovo‐Taboada José; Díaz‐López Mario; Bastón‐Rey Iria; Domínguez‐Mu?oz Juan Enrique

摘要

Abstract <section numbered="no" xml:id="hel12440-sec-0001"> <title type="main">Background > The rate of H. pylori resistance to different antibiotics is increasing and determines the selection of eradication therapy. The aim of this study was to determine the resistance patterns of H. pylori strains in our area. </section> <section numbered="no" xml:id="hel12440-sec-0002"> <title type="main">Methods > Biopsies from gastric corpus for microbiological culture and antibiotic resistance were obtained in patients undergoing upper gastrointestinal endoscopy for dyspepsia. Selective Agar Pylori for isolation of the bacteria and Agar Mueller‐Hinton supplemented with blood to test the sensitivity to antibiotics were used. Presence of H. pylori was confirmed using direct observation with phase‐contrast microscopy and/or smears stained with acridine orange. In vitro bacterial susceptibility to amoxicillin, clarithromycin, rifampicin, tetracycline, metronidazole, and levofloxacin was tested using diffusion MIC test strips. Minimum inhibitory concentration values were determined based on the 6th version of the EUCAST (European Committee on Antimicrobial Susceptibility Testing) Clinical Breakpoint (2016). </section> <section numbered="no" xml:id="hel12440-sec-0003"> <title type="main">Results > Two hundred and seventeen patients were included (58.1% female, median age 64?years, range 25‐92). H. pylori was identified in 108 patients (49.8%); culture and antibiogram were completed in 77 of them (71.3% of H. pylori ‐positive patients). The resistance rates were as follows: lev </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“Hel12440-Abs-0001”> <标题类型=“main”>抽象</ title> <secueeded =“no”xml：id =“hel12440-sec-0001” > <标题类型=“main”>背景</ title> > h的速率。 Pylori </ i>对不同抗生素的抗性正在增加并决定根除治疗的选择。本研究的目的是确定 h的电阻模式。幽门螺杆菌</ i>我们地区的菌株。 </ p> </段> <部分编号=“否”XML：ID =“Hel12440-SEC-0002”> <标题类型=“main”>方法</标题> >微生物培养的胃癌中的活检在接受上胃肠内镜内窥镜治疗的患者中获得抗生素抗性。选择性琼脂幽门螺杆菌用于分离细菌和琼脂Mueller-Hinton，补充有血液以测试对抗生素的敏感性。存在 h。使用与吖啶橙染色的相位对比显微镜和/或涂片进行直接观察，确认Pylori </ i>。使用扩散MIC试管测试对阿莫西林，克拉霉素，利福平，四环素，甲硝唑和左氧氟沙星的体外细菌敏感性。基于果树的第6版（欧洲抗菌易感性测试）临床断点（2016）确定最小抑制浓度值。 </ p> </ section> <部分编号=“否”XML：ID =“HEL12440-SEC-0003”> <标题类型=“MAIN”>结果</标题> <P>二百和十七名患者被包括在内（58.1％的女性，64岁时的中位数64岁，范围为25-92）。 h。幽门螺杆菌在108名患者中鉴定（49.8％）;培养和抗体诊断在其中77中完成（71.3％的 h。幽门螺杆菌</ i> - 阳性患者）。阻力率如下：LEV </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2017年第6期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Macías‐García Fernando&option=202" target="_blank" rel="nofollow">Macías‐García Fernando;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Llovo‐Taboada José&option=202" target="_blank" rel="nofollow">Llovo‐Taboada José;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Díaz‐López Mario&option=202" target="_blank" rel="nofollow">Díaz‐López Mario;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bastón‐Rey Iria&option=202" target="_blank" rel="nofollow">Bastón‐Rey Iria;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Domínguez‐Mu?oz Juan Enrique&option=202" target="_blank" rel="nofollow">Domínguez‐Mu?oz Juan Enrique;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Gastroenterology and HepatologyUniversity Hospital of Santiago de CompostelaSantiago de Compostela Spain;</p> <p>Department of MicrobiologyUniversity Hospital of Santiago de CompostelaSantiago de Compostela Spain;</p> <p>Department of Gastroenterology and HepatologyUniversity Hospital of Santiago de CompostelaSantiago de Compostela Spain;</p> <p>Department of Gastroenterology and HepatologyUniversity Hospital of Santiago de CompostelaSantiago de Compostela Spain;</p> <p>Department of Gastroenterology and HepatologyUniversity Hospital of Santiago de CompostelaSantiago de Compostela Spain;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antibiotic resistance&option=203" rel="nofollow">antibiotic resistance;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=culture&option=203" rel="nofollow">culture;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=H.?pylori&option=203" rel="nofollow">H.?pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=H.?pylori eradication&option=203" rel="nofollow">H.?pylori eradication;</a> </p> <div class="translation"> 机译：抗生素抗性;培养;H.？幽门螺杆菌;H.？幽门螺杆菌根除; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025098876.html">High primary antibiotic resistance of <i >Helicobacter PyloriHelicobacter Pylori strains 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class="tuijian_auth tuijian_authcolor"> . 李锐</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=于丹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,于丹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李淑芹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李淑芹</a> <span> <a href="/journal-cn-6421/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国现代药物应用 </a> </span> <span> . 2019</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-242_thesis/02022351499.html">幽门螺杆菌根除治疗对幽门螺杆菌阳性的功能性消化不良患者的治疗效果</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李倩倩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李倩倩</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢红燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谢红燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯劲东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冯劲东</a> <span> <a href="/conference-cn-242/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2016年《中国医院药学杂志》学术年会 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031433750.html">根除幽门螺杆菌对功能性消化不良患者影响的临床研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张强</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204146352.html">一种幽门螺杆菌菌株分离培养的方法</a> <b>[P]</b> . <span> 中国专利： CN109880772B </span> <span> . 2020.12.08</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100764525.html">一种幽门螺杆菌菌株分离培养的方法</a> <b>[P]</b> . <span> 中国专利： CN109880772A </span> <span> . 2019-06-14</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130441612636.html">GENES OF HELICOBACTER PYLORI 51 STRAIN ISOLATED FROM KOREAN PATIENT</a> <b>[P]</b> . <span> 外国专利：  KR20040072913A </span> <span> . 2004-08-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：分离自韩国患者的幽门螺杆菌51株的基因 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130443262008.html">BASE SEQUENCE OF pbp1 GENE OF CLINICAL ISOLATE OF HELICOBACTER PYLORI, ASSOCIATED WITH RESISTANCE TO AMOXICILLIN OF b-LACTAM-BASED ANTIBIOTIC, VARIATION OF AMINO ACID SEQUENCE BASED THEREON, VARIANT OF HELICOBACTER PYLORI HAVING THE VARIATION, DIAGNOSIS THEREOF AND METHOD FOR UTILIZING THE SAME FOR DEVELOPMENT OF THERAPEUTIC METHOD</a> <b>[P]</b> . <span> 外国专利：  JP2004121141A </span> <span> . 2004-04-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：幽门螺杆菌临床分离株pbp1基因的碱基序列，与基于β-内酰胺的抗生素对阿米西林的耐药性有关，基于此的氨基酸序列变化，变种的幽门螺旋菌及其治疗方法及其变化治疗方法的发展 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130408584583.html">A antibiotic composition for Helicobacter pylori containing the propolis extraction fractions thereof or subfractional extrats isolated therefrom</a> <b>[P]</b> . <span> 外国专利：  KR101750854B1 </span> <span> . 2017-06-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于幽门螺杆菌的抗生素组合物，其包含蜂胶提取级分或从中分离出的次分馏分 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" 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High primary antibiotic resistance of Helicobacter PyloriHelicobacter Pylori strains isolated from dyspeptic patients: A prevalence cross‐sectional study in Spain

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